Relationship between the serotonin receptor 1A polymorphism with treatment response to escitalopram in patients with major depresive disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soo, Chang H. | - |
dc.contributor.author | Choi, I.-K. | - |
dc.contributor.author | Lee, H.-Y. | - |
dc.contributor.author | Jeong, Y.-J. | - |
dc.contributor.author | Kim, B. | - |
dc.contributor.author | Lee, M.-S. | - |
dc.date.accessioned | 2021-09-06T09:49:27Z | - |
dc.date.available | 2021-09-06T09:49:27Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1724-4935 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105913 | - |
dc.description.abstract | Objective: Serotonin 1A receptor (HTR1A) is a candidate molecule for influencing the pathophysiology of major depressive disorder (MDD) and clinical responses to antidepressant treatment. Among polymorphisms of the HTR1A gene, -1019C>G (rs6295) is reportedly a biologically functional polymorphism associated with response to antidepressant treatment. The aim of this study was to determine the relationship between the HTR1A-1019C>G polymorphism and the response to escitalopram in patients with MD. Method: Eighty Korean patients were examined using the Structured Clinical Interview for DSM-IV Axis I disorders and took escitalopram at a daily dose of 5 to 40 mg. Clinical symptoms were evaluated using the 21-item Hamilton Depression Rating (HAM-D) scale during 8 weeks of treatment. The genotypes were determined using HpyCH4 IV digestion following polymerase chain reaction. Results: The proportion of G-allele carriers was 25.0% in responders, which was lower than that in non-responders (53.9%) at 1 week of escitalopram treatment (OR = 0.28, P = 0.030). In allelic analysis, the frequency of the G allele was significantly lower in responders at 1 week than in non-responders (12.5% versus 31.7%, respectively; OR = 0.29, P = 0.029). Similarly, the ratio of HAM-D score at 1 week to the baseline score in C-allele carriers was 67.6% ± 2.42%, which was significantly lower than the ratio of 75.8% ± 2.74% in patients possessing the G allele (P = 0.027). Conclusions: Although this study is preliminary and has several limitations, our results suggest that HTR1A- 1019C>G may be a genetic marker predicting the response to escitalopram treatment. © 2013 Giovanni Fioriti Editore s.r.l. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | cytosine | - |
dc.subject | escitalopram | - |
dc.subject | guanine | - |
dc.subject | restriction endonuclease | - |
dc.subject | serotonin 1A receptor | - |
dc.subject | adult | - |
dc.subject | aged | - |
dc.subject | allele | - |
dc.subject | article | - |
dc.subject | disease severity | - |
dc.subject | DNA extraction | - |
dc.subject | female | - |
dc.subject | gene amplification | - |
dc.subject | gene expression | - |
dc.subject | genetic analysis | - |
dc.subject | genetic association | - |
dc.subject | genetic marker | - |
dc.subject | genetic polymorphism | - |
dc.subject | genetic variability | - |
dc.subject | genotype | - |
dc.subject | Hamilton scale | - |
dc.subject | heterozygote | - |
dc.subject | HTR1A gene | - |
dc.subject | human | - |
dc.subject | major clinical study | - |
dc.subject | major depression | - |
dc.subject | male | - |
dc.subject | pharmacogenetics | - |
dc.subject | polymerase chain reaction | - |
dc.subject | remission | - |
dc.subject | single nucleotide polymorphism | - |
dc.subject | Structured Clinical Interview for DSM Disorders | - |
dc.subject | symptom assessment | - |
dc.subject | treatment response | - |
dc.title | Relationship between the serotonin receptor 1A polymorphism with treatment response to escitalopram in patients with major depresive disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, M.-S. | - |
dc.identifier.scopusid | 2-s2.0-84885042242 | - |
dc.identifier.bibliographicCitation | Clinical Neuropsychiatry, v.10, no.3-4, pp.148 - 154 | - |
dc.relation.isPartOf | Clinical Neuropsychiatry | - |
dc.citation.title | Clinical Neuropsychiatry | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 148 | - |
dc.citation.endPage | 154 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | cytosine | - |
dc.subject.keywordPlus | escitalopram | - |
dc.subject.keywordPlus | guanine | - |
dc.subject.keywordPlus | restriction endonuclease | - |
dc.subject.keywordPlus | serotonin 1A receptor | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | allele | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | disease severity | - |
dc.subject.keywordPlus | DNA extraction | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene amplification | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | genetic analysis | - |
dc.subject.keywordPlus | genetic association | - |
dc.subject.keywordPlus | genetic marker | - |
dc.subject.keywordPlus | genetic polymorphism | - |
dc.subject.keywordPlus | genetic variability | - |
dc.subject.keywordPlus | genotype | - |
dc.subject.keywordPlus | Hamilton scale | - |
dc.subject.keywordPlus | heterozygote | - |
dc.subject.keywordPlus | HTR1A gene | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | major depression | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | pharmacogenetics | - |
dc.subject.keywordPlus | polymerase chain reaction | - |
dc.subject.keywordPlus | remission | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordPlus | Structured Clinical Interview for DSM Disorders | - |
dc.subject.keywordPlus | symptom assessment | - |
dc.subject.keywordPlus | treatment response | - |
dc.subject.keywordAuthor | Escitalopram | - |
dc.subject.keywordAuthor | Major depressive disorder | - |
dc.subject.keywordAuthor | Serotonin receptor 1A | - |
dc.subject.keywordAuthor | Single-nucleotide polymorphism | - |
dc.subject.keywordAuthor | Treatment response | - |
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