Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance
DC Field | Value | Language |
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dc.contributor.author | Yang, S.J. | - |
dc.contributor.author | Kim, T.N. | - |
dc.contributor.author | Baik, S.H. | - |
dc.contributor.author | Kim, T.S. | - |
dc.contributor.author | Lee, K.W. | - |
dc.contributor.author | Nam, M. | - |
dc.contributor.author | Park, Y.S. | - |
dc.contributor.author | Woo, J.-T. | - |
dc.contributor.author | Kim, Y.S. | - |
dc.contributor.author | Kim, S.-H. | - |
dc.date.accessioned | 2021-09-06T09:54:02Z | - |
dc.date.available | 2021-09-06T09:54:02Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/105940 | - |
dc.description.abstract | Background/Aims: The aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM). Methods: A cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose ≥ 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281). Results: The GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin sensitivity check index, homeostasis model assessment for estimation of index β-cell secretion (HOMA-B), first and second phase insulin secretion, and insulin secretion- sensitivity index (ISSI) than the NGT group (p ≤ 0.001 for all). Moreover, the GIGT group had lower ISOGTT, HOMA-B, first and second phase insulin secretion, and ISSI than the NGT group (p < 0.001 for all). Among the GIGT subjects, the 1-hour plasma glucose abnormal levels group showed significantly greater weight gain during pregnancy and higher values in the 50-g OGCT than the other two groups. Moreover, the 1-hour and 2-hour abnormal levels groups had poorer insulin secretion status than the 3-hour abnormal levels group. Conclusions: Korean women with GDM show impairments of both insulin secretion and insulin sensitivity. In addition, GIGT is associated with both β-cell dysfunction and insulin resistance. © 2013 The Korean Association of Internal Medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | glucose | - |
dc.subject | adult | - |
dc.subject | article | - |
dc.subject | body mass | - |
dc.subject | clinical feature | - |
dc.subject | controlled study | - |
dc.subject | cross-sectional study | - |
dc.subject | female | - |
dc.subject | glucose blood level | - |
dc.subject | glucose homeostasis | - |
dc.subject | glucose metabolism | - |
dc.subject | high risk pregnancy | - |
dc.subject | human | - |
dc.subject | hyperglycemia | - |
dc.subject | impaired glucose tolerance | - |
dc.subject | insulin release | - |
dc.subject | insulin resistance | - |
dc.subject | insulin sensitivity | - |
dc.subject | Korea | - |
dc.subject | major clinical study | - |
dc.subject | oral glucose challenge test | - |
dc.subject | oral glucose tolerance test | - |
dc.subject | pancreas islet beta cell | - |
dc.subject | pregnancy diabetes mellitus | - |
dc.subject | pregnant woman | - |
dc.subject | provocation test | - |
dc.subject | Gestational diabetes mellitus | - |
dc.subject | Gestational impaired glucose tolerance | - |
dc.subject | Insulin resistance | - |
dc.subject | Insulin secretion | - |
dc.subject | Adult | - |
dc.subject | Cross-Sectional Studies | - |
dc.subject | Diabetes, Gestational | - |
dc.subject | Female | - |
dc.subject | Glucose Tolerance Test | - |
dc.subject | Humans | - |
dc.subject | Insulin | - |
dc.subject | Insulin Resistance | - |
dc.subject | Pregnancy | - |
dc.title | Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, S.H. | - |
dc.identifier.doi | 10.3904/kjim.2013.28.3.306 | - |
dc.identifier.scopusid | 2-s2.0-84878025630 | - |
dc.identifier.bibliographicCitation | Korean Journal of Internal Medicine, v.28, no.3, pp.306 - 313 | - |
dc.relation.isPartOf | Korean Journal of Internal Medicine | - |
dc.citation.title | Korean Journal of Internal Medicine | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 306 | - |
dc.citation.endPage | 313 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001766171 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | body mass | - |
dc.subject.keywordPlus | clinical feature | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cross-sectional study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | glucose blood level | - |
dc.subject.keywordPlus | glucose homeostasis | - |
dc.subject.keywordPlus | glucose metabolism | - |
dc.subject.keywordPlus | high risk pregnancy | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | hyperglycemia | - |
dc.subject.keywordPlus | impaired glucose tolerance | - |
dc.subject.keywordPlus | insulin release | - |
dc.subject.keywordPlus | insulin resistance | - |
dc.subject.keywordPlus | insulin sensitivity | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | oral glucose challenge test | - |
dc.subject.keywordPlus | oral glucose tolerance test | - |
dc.subject.keywordPlus | pancreas islet beta cell | - |
dc.subject.keywordPlus | pregnancy diabetes mellitus | - |
dc.subject.keywordPlus | pregnant woman | - |
dc.subject.keywordPlus | provocation test | - |
dc.subject.keywordPlus | Gestational diabetes mellitus | - |
dc.subject.keywordPlus | Gestational impaired glucose tolerance | - |
dc.subject.keywordPlus | Insulin resistance | - |
dc.subject.keywordPlus | Insulin secretion | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Cross-Sectional Studies | - |
dc.subject.keywordPlus | Diabetes, Gestational | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Glucose Tolerance Test | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Insulin | - |
dc.subject.keywordPlus | Insulin Resistance | - |
dc.subject.keywordPlus | Pregnancy | - |
dc.subject.keywordAuthor | Insulin resistance | - |
dc.subject.keywordAuthor | Insulin secretion | - |
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