Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor
- Authors
- Kang, K.; Park, J.H.; Ryu, J.Y.; Lee, S.Y.; Ko, G.J.; Kwon, Y.J.
- Issue Date
- 2013
- Keywords
- Anaplastic thyroid carcinoma; G-CSF; Paraneoplastic leukocytosis
- Citation
- Blood Research, v.48, no.1, pp.63 - 66
- Indexed
- SCOPUS
KCI
- Journal Title
- Blood Research
- Volume
- 48
- Number
- 1
- Start Page
- 63
- End Page
- 66
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105983
- DOI
- 10.5045/br.2013.48.1.63
- ISSN
- 2287-979X
- Abstract
- Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay.Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis. © 2013 Korean Society of Hematology.
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