Is it Feasible to Use the Commercially Available Autoquantitation Software for the Evaluation of Myocardial Viability on Small-Animal Cardiac F-18 FDG PET Scan?
DC Field | Value | Language |
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dc.contributor.author | Pahk, K. | - |
dc.contributor.author | Oh, S.Y. | - |
dc.contributor.author | Jeong, E. | - |
dc.contributor.author | Lee, S.H. | - |
dc.contributor.author | Woo, S.K. | - |
dc.contributor.author | Yu, J.W. | - |
dc.contributor.author | Choe, J.G. | - |
dc.contributor.author | Cheon, G.J. | - |
dc.date.accessioned | 2021-09-06T10:07:39Z | - |
dc.date.available | 2021-09-06T10:07:39Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106026 | - |
dc.description.abstract | Purpose: To evaluate the reliability of quantitation of myocardial viability on cardiac F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) scans with three different methods of visual scoring system, autoquantitation using commercially available autoquantitation software, and infarct-size measurement using histogram-based maximum pixel threshold identification on polar-map in rat hearts. Methods: A myocardial infarct (MI) model was made by left anterior descending artery (LAD) ligation in rat hearts. Eighteen MI rats underwent cardiac FDG-PET-computed tomography (CT) twice within a 4-week interval. Myocardium was partitioned into 20 segments for the comparison, and then we quantitated non-viable myocardium on cardiac FDG PET-CT with three different methods: method A-infarct-size measurement using histogram-based maximum pixel threshold identification on polar-map; method B-summed MI score (SMS) by a four-point visual scoring system; method C-metabolic non-viable values by commercially available autoquantitation software. Changes of non-viable myocardium on serial PET-CT scans with three different methods were calculated by the change of each parameter. Correlation and reproducibility were evaluated between the different methods. Results: Infarct-size measurement, visual SMS, and non-viable values by autoquantitation software presented proportional relationship to each other. All the parameters of methods A, B, and C showed relatively good correlation between each other. Among them, infarct-size measurement (method A) and autoquantitation software (method C) showed the best correlation (r = 0.87, p < 0.001). When we evaluated the changes of non-viable myocardium on the serial FDG-PET-CT- however, autoquantitation program showed less correlation with the other methods. Visual assessment (method B) and those of infarct size (method A) showed the best correlation (r = 0.54, p = 0.02) for the assessment of interval changes. Conclusions: Commercially available quantitation software could be applied to measure the myocardial viability on small animal cardiac FDG-PET-CT scan. This kind of quantitation showed good correlation with infarct size measurement by histogram-based maximum pixel threshold identification. However, this method showed the weak correlation when applied in the measuring the changes of non-viable myocardium on the serial scans, which means that the caution will be needed to evaluate the changes on the serial monitoring. © 2013 Korean Society of Nuclear Medicine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | fluorodeoxyglucose f 18 | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | article | - |
dc.subject | computer program | - |
dc.subject | controlled study | - |
dc.subject | correlation coefficient | - |
dc.subject | feasibility study | - |
dc.subject | heart infarction | - |
dc.subject | heart infarction size | - |
dc.subject | heart muscle | - |
dc.subject | image analysis | - |
dc.subject | image processing | - |
dc.subject | left anterior descending coronary artery | - |
dc.subject | limit of quantitation | - |
dc.subject | male | - |
dc.subject | nonhuman | - |
dc.subject | PET scanner | - |
dc.subject | positron emission tomography | - |
dc.subject | priority journal | - |
dc.subject | rat | - |
dc.subject | reliability | - |
dc.subject | reproducibility | - |
dc.subject | scoring system | - |
dc.title | Is it Feasible to Use the Commercially Available Autoquantitation Software for the Evaluation of Myocardial Viability on Small-Animal Cardiac F-18 FDG PET Scan? | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, S.H. | - |
dc.contributor.affiliatedAuthor | Choe, J.G. | - |
dc.identifier.doi | 10.1007/s13139-013-0206-8 | - |
dc.identifier.scopusid | 2-s2.0-84877838553 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.47, no.2, pp.104 - 114 | - |
dc.relation.isPartOf | Nuclear Medicine and Molecular Imaging | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 104 | - |
dc.citation.endPage | 114 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001775636 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | fluorodeoxyglucose f 18 | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | computer program | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | correlation coefficient | - |
dc.subject.keywordPlus | feasibility study | - |
dc.subject.keywordPlus | heart infarction | - |
dc.subject.keywordPlus | heart infarction size | - |
dc.subject.keywordPlus | heart muscle | - |
dc.subject.keywordPlus | image analysis | - |
dc.subject.keywordPlus | image processing | - |
dc.subject.keywordPlus | left anterior descending coronary artery | - |
dc.subject.keywordPlus | limit of quantitation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | PET scanner | - |
dc.subject.keywordPlus | positron emission tomography | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | reliability | - |
dc.subject.keywordPlus | reproducibility | - |
dc.subject.keywordPlus | scoring system | - |
dc.subject.keywordAuthor | Autoquantitation | - |
dc.subject.keywordAuthor | FDG PET | - |
dc.subject.keywordAuthor | Myocardial infarct model | - |
dc.subject.keywordAuthor | Myocardial viability | - |
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