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Size-dependent plasmonic responses of single gold nanoparticles for analysis of biorecognition

Authors
Hwang, Woo SungPhuoc Long TruongSim, Sang Jun
Issue Date
1-2월-2012
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Localized surface plasmon resonance (LSPR); Gold nanoparticle (AuNP); Biomolecular recognition; Resonant Rayleigh light scattering
Citation
ANALYTICAL BIOCHEMISTRY, v.421, no.1, pp.213 - 218
Indexed
SCIE
SCOPUS
Journal Title
ANALYTICAL BIOCHEMISTRY
Volume
421
Number
1
Start Page
213
End Page
218
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106084
DOI
10.1016/j.ab.2011.11.001
ISSN
0003-2697
Abstract
We report the use of plasmonic responses of single gold nanoparticles (AuNPs) with various sizes for the analysis of biomolecular recognition. We also describe the relationship between particle size and plasmonic response induced by the binding of receptors and target analytes. To investigate the plasmonic response of AuNPs. Rayleigh light scattering spectra were collected from individual AuNPs using a dark-field microspectroscopy system. Using prostate-specific antigen (PSA) as a model, the linear dynamic range was obtained in the concentration range of 10(-4) to 10 ng/ml, with the smallest detectable concentration at 0.1 pg/ml corresponding to localized surface plasmon resonance (LSPR) lambda(max) shifts of approximately 2.95 nm. This result indicates that individual AuNPs can be used for development of a very sensitive, robust, simple, and label-free biosensor to detect protein biomarkers. Furthermore, the method possesses great potential for monitoring other biological interactions. (C) 2011 Elsevier Inc. All rights reserved.
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공과대학 (화공생명공학과)
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