Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T10:22:54Z | - |
dc.date.available | 2021-09-06T10:22:54Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106097 | - |
dc.description.abstract | To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). A meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and lupus nephritis (LN) (when available) using (1) the allele contrast, (2) the recessive, (3) the dominant, and (4) the additive models. A total of eight studies, which included 1,297 cases and 1,214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in any study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphism and LN in SLE patients [odds ratio (OR) = 2.125, 95% confidence interval (CI) = 1.289-3.054, p = 0.003; OR = 2.655, 95% CI = 1.509-4.671, p = 0.001]. No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency to an association between the TT genotype and SLE (OR = 1.220, 95% CI = 1.000-1.489, p = 0.050), and meta-analysis of the TT versus CC genotype of the C786T polymorphism in group in Hardy-Weinberg equilibrium revealed a significant association between the TT genotype and SLE (OR = 1.643, 95% CI = 1.021-2.644, p = 0.041). This meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | GENE POLYMORPHISM | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | CHINESE POPULATION | - |
dc.subject | DISEASE | - |
dc.subject | ARTERY | - |
dc.subject | RISK | - |
dc.subject | SLE | - |
dc.title | Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-011-0397-3 | - |
dc.identifier.scopusid | 2-s2.0-84863129516 | - |
dc.identifier.wosid | 000299525300006 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.61, no.2, pp.135 - 141 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 61 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 135 | - |
dc.citation.endPage | 141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISM | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | CHINESE POPULATION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ARTERY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Endothelial nitric oxide synthase | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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