Macrophages as Cell-Based Delivery Systems for Nanoshells in Photothermal Therapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Madsen, Steen J. | - |
dc.contributor.author | Baek, Seung-Kuk | - |
dc.contributor.author | Makkouk, Amani R. | - |
dc.contributor.author | Krasieva, Tatiana | - |
dc.contributor.author | Hirschberg, Henry | - |
dc.date.accessioned | 2021-09-06T10:25:00Z | - |
dc.date.available | 2021-09-06T10:25:00Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0090-6964 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106110 | - |
dc.description.abstract | Site-specific delivery of nanoparticles poses a significant challenge, especially in the brain where the blood-brain barrier prevents the entry of most therapeutic compounds including nanoparticle-based anti-cancer agents. In this context, the use of macrophages as vectors for the delivery of gold-silica nanoshells to infiltrating gliomas will be reviewed in this article. Gold-silica nanoshells are readily phagocytosed by macrophages without any apparent toxic effects, and the results of in vitro studies have demonstrated the migratory potential of nanoshell-loaded macrophages in human glioma spheroids. Of particular interest is the observation that, after near-infrared exposure of spheroids containing nanoshell-loaded macrophages, sufficient heat was generated to suppress spheroid growth. Collectively, these findings demonstrate the potential of macrophages as nanoshell delivery vectors for photothermal therapy of gliomas, and they certainly provide the basis for future animal studies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | BLOOD-BRAIN-BARRIER | - |
dc.subject | GOLD NANOSHELLS | - |
dc.subject | TUMOR SPHEROIDS | - |
dc.subject | ABLATION | - |
dc.subject | NANOPARTICLES | - |
dc.subject | IMMUNONANOSHELLS | - |
dc.subject | GLIOMA | - |
dc.title | Macrophages as Cell-Based Delivery Systems for Nanoshells in Photothermal Therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baek, Seung-Kuk | - |
dc.identifier.doi | 10.1007/s10439-011-0415-1 | - |
dc.identifier.scopusid | 2-s2.0-84858793809 | - |
dc.identifier.wosid | 000300485100018 | - |
dc.identifier.bibliographicCitation | ANNALS OF BIOMEDICAL ENGINEERING, v.40, no.2, pp.507 - 515 | - |
dc.relation.isPartOf | ANNALS OF BIOMEDICAL ENGINEERING | - |
dc.citation.title | ANNALS OF BIOMEDICAL ENGINEERING | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 507 | - |
dc.citation.endPage | 515 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | GOLD NANOSHELLS | - |
dc.subject.keywordPlus | TUMOR SPHEROIDS | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | IMMUNONANOSHELLS | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Gold-silica nanoshells | - |
dc.subject.keywordAuthor | Gliomas | - |
dc.subject.keywordAuthor | Spheroids | - |
dc.subject.keywordAuthor | Blood-brain barrier | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.