Candidate gene studies of fibromyalgia: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T10:31:07Z | - |
dc.date.available | 2021-09-06T10:31:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106147 | - |
dc.description.abstract | The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | O-METHYLTRANSFERASE GENE | - |
dc.subject | 5-HT2A RECEPTOR GENE | - |
dc.subject | T102C POLYMORPHISM | - |
dc.subject | FUNCTIONAL POLYMORPHISM | - |
dc.subject | REGULATORY REGION | - |
dc.subject | ASSOCIATION | - |
dc.subject | SEROTONIN | - |
dc.subject | TRANSPORTER | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | EXPRESSION | - |
dc.title | Candidate gene studies of fibromyalgia: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00296-010-1678-9 | - |
dc.identifier.scopusid | 2-s2.0-84857039290 | - |
dc.identifier.wosid | 000299507900021 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.32, no.2, pp.417 - 426 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 426 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | O-METHYLTRANSFERASE GENE | - |
dc.subject.keywordPlus | 5-HT2A RECEPTOR GENE | - |
dc.subject.keywordPlus | T102C POLYMORPHISM | - |
dc.subject.keywordPlus | FUNCTIONAL POLYMORPHISM | - |
dc.subject.keywordPlus | REGULATORY REGION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | TRANSPORTER | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Candidate gene | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Fibromyalgia | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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