The role of critical shear stress on acute coronary syndrome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jongyoun | - |
dc.contributor.author | Chung, Hyemoon | - |
dc.contributor.author | Cho, Minhee | - |
dc.contributor.author | Lee, Byoung-Kwon | - |
dc.contributor.author | Karimi, Ali | - |
dc.contributor.author | Shin, Sehyun | - |
dc.date.accessioned | 2021-09-06T11:12:38Z | - |
dc.date.available | 2021-09-06T11:12:38Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1386-0291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106414 | - |
dc.description.abstract | Increased aggregation of RBC is associated with many vascular diseases, including acute coronary syndrome (ACS). Critical shear-stress (CSS) as in index of red cell aggregation is defined as either the minimum shear-stress required dispersing the aggregates. The objective of this study is to access the role of CSS in ACS comparing to SA, and to evaluate the correlation with usual biomarkers for atherosclerosis such as fibrinogen, hs-CRP. 169 SA and 223 ACS patients were finally enrolled. A detailed medical history and laboratory data were obtained for each participant from clinical records. CSS is measured by simultaneous measurement of shear stress and light backscattering using a small disposable kit with a microfluidic hemorheometer. We hypothesized that higher value of CSS might be associated increased thrombosis in ACS. As results, relatively younger age was shown and more male in ACS patients, and inflammatory markers (WBC, hs-CRP) were higher in ACS. Whole blood viscosities were significantly higher in ACS than SA along at all shear rates. CSS was 25.7% higher in ACS (333.8 +/- 147.8) than in SA (265.4 +/- 149.9 mPa) (p < 0.001). CSS was highly correlated white blood cell counts, hs-CRP, fibrinogen, and erythrocyte sedimentation rate (ESR). Among those variables, fibrinogen, and ESR were strongly correlated with CSS. We may suggest that CSS could be used as a novel risk marker for ACS. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | BLOOD-CELL AGGREGATION | - |
dc.subject | RISK-ASSESSMENT STRATEGIES | - |
dc.subject | ERYTHROCYTE AGGREGATION | - |
dc.subject | VULNERABLE PATIENT | - |
dc.subject | DEFORMABILITY | - |
dc.subject | DEFINITIONS | - |
dc.subject | PLAQUES | - |
dc.subject | TRIGGER | - |
dc.subject | CALL | - |
dc.title | The role of critical shear stress on acute coronary syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Sehyun | - |
dc.identifier.doi | 10.3233/CH-131694 | - |
dc.identifier.scopusid | 2-s2.0-84887890393 | - |
dc.identifier.wosid | 000326653200012 | - |
dc.identifier.bibliographicCitation | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.55, no.1, pp.101 - 109 | - |
dc.relation.isPartOf | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.title | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 109 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | BLOOD-CELL AGGREGATION | - |
dc.subject.keywordPlus | RISK-ASSESSMENT STRATEGIES | - |
dc.subject.keywordPlus | ERYTHROCYTE AGGREGATION | - |
dc.subject.keywordPlus | VULNERABLE PATIENT | - |
dc.subject.keywordPlus | DEFORMABILITY | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | TRIGGER | - |
dc.subject.keywordPlus | CALL | - |
dc.subject.keywordAuthor | Critical shear stress | - |
dc.subject.keywordAuthor | RBC aggregation | - |
dc.subject.keywordAuthor | acute coronary syndrome | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.