An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)
DC Field | Value | Language |
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dc.contributor.author | Jung, Wooseok | - |
dc.contributor.author | Han, Jungyoup | - |
dc.contributor.author | Kai, Junhai | - |
dc.contributor.author | Lim, Ji-Youn | - |
dc.contributor.author | Sul, Donggeun | - |
dc.contributor.author | Ahn, Chong H. | - |
dc.date.accessioned | 2021-09-06T11:16:29Z | - |
dc.date.available | 2021-09-06T11:16:29Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106436 | - |
dc.description.abstract | A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single-channel assay system, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Test results were obtained within 30 minutes after a sample was dropped into the POCT cartridge. The analyzed results of TSH showed a linear range of up to 55 mu IU mL(-1) with the limit of detection (LOD) of 1.9 mu IU mL(-1) at the signal-to-noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained more than 97% of their initial volume for 120 days of storage time while the detection antibody retained its activity above 98% for 120 days. The sample-to-answer polymer lab-on-a-chip developed in this work using the mass-producible and low-cost polymer is well suited for the point-of-care testing of rapid in vitro diagnostics (IVD) of TSH. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | IMMUNOASSAY | - |
dc.subject | ASSAY | - |
dc.subject | MICROFLUIDICS | - |
dc.title | An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, Donggeun | - |
dc.identifier.doi | 10.1039/c3lc50403d | - |
dc.identifier.scopusid | 2-s2.0-84888164549 | - |
dc.identifier.wosid | 000326983300020 | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.13, no.23, pp.4653 - 4662 | - |
dc.relation.isPartOf | LAB ON A CHIP | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 13 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 4653 | - |
dc.citation.endPage | 4662 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.subject.keywordPlus | IMMUNOASSAY | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | MICROFLUIDICS | - |
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