Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: a meta-analysis

Abstract

Objective: The aim of this study was to determine whether interleukin (IL)-23R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR] = 0.624, 95% confidence interval [CI] = 0.565-0.697, p<1.0 x 10(-8); OR = 0.804, 95% CI = 0.743-0.869, p = 3.0 x 10(-7), respectively). Meta-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR = 0.710, 95% CI = 0.673-0.749, p<1.0 x 10(-8); OR = 0.684, 95% CI = 0.639-0.731, p<1.0 x 10(-8), respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.