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A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

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dc.contributor.authorBhuniya, Sankarprasad-
dc.contributor.authorLee, Min Hee-
dc.contributor.authorJeon, Hyun Mi-
dc.contributor.authorHan, Ji Hye-
dc.contributor.authorLee, Jae Hong-
dc.contributor.authorPark, Nayoung-
dc.contributor.authorMaiti, Sukhendu-
dc.contributor.authorKang, Chulhun-
dc.contributor.authorKim, Jong Seung-
dc.date.accessioned2021-09-06T11:24:18Z-
dc.date.available2021-09-06T11:24:18Z-
dc.date.created2021-06-14-
dc.date.issued2013-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/106485-
dc.description.abstractWe present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectAPPENDED NAPHTHALIMIDE-
dc.subjectTARGETED DELIVERY-
dc.subjectDRUG-RELEASE-
dc.subjectNANOPARTICLES-
dc.subjectPRODRUG-
dc.subjectAPOPTOSIS-
dc.subjectTHERAPY-
dc.titleA fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Jong Seung-
dc.identifier.doi10.1039/c3cc42653j-
dc.identifier.scopusid2-s2.0-84880340647-
dc.identifier.wosid000321827600012-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.49, no.64, pp.7141 - 7143-
dc.relation.isPartOfCHEMICAL COMMUNICATIONS-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume49-
dc.citation.number64-
dc.citation.startPage7141-
dc.citation.endPage7143-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusAPPENDED NAPHTHALIMIDE-
dc.subject.keywordPlusTARGETED DELIVERY-
dc.subject.keywordPlusDRUG-RELEASE-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusPRODRUG-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusTHERAPY-
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