SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
DC Field | Value | Language |
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dc.contributor.author | Jung, Wonkyung | - |
dc.contributor.author | Hong, Kwang Dae | - |
dc.contributor.author | Jung, Woon Yong | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Shin, Bong Kyung | - |
dc.contributor.author | Kim, Han Kyeom | - |
dc.contributor.author | Kim, Aeree | - |
dc.contributor.author | Kim, Baek-Hui | - |
dc.date.accessioned | 2021-09-06T11:25:11Z | - |
dc.date.available | 2021-09-06T11:25:11Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106490 | - |
dc.description.abstract | Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as beta-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, beta-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of beta-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p = 0.029) and altered expression of beta-catenin (p = 0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p = 0.001), beta-catenin (p = 0.001), and survivin (p = 0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with beta-catenin and survivin rather than p53. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.subject | HISTONE DEACETYLASE EXPRESSION | - |
dc.subject | BETA-CATENIN | - |
dc.subject | NEGATIVE REGULATOR | - |
dc.subject | COLON-CANCER | - |
dc.subject | SURVIVIN | - |
dc.subject | DBC1 | - |
dc.subject | P53 | - |
dc.subject | SYNTHASE | - |
dc.subject | COMPLEX | - |
dc.subject | BREAST | - |
dc.title | SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Woon Yong | - |
dc.contributor.affiliatedAuthor | Shin, Bong Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Han Kyeom | - |
dc.contributor.affiliatedAuthor | Kim, Aeree | - |
dc.contributor.affiliatedAuthor | Kim, Baek-Hui | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2013.47.4.332 | - |
dc.identifier.scopusid | 2-s2.0-84884563591 | - |
dc.identifier.wosid | 000323609600004 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.47, no.4, pp.332 - 339 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 332 | - |
dc.citation.endPage | 339 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001795026 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE EXPRESSION | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | NEGATIVE REGULATOR | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | SURVIVIN | - |
dc.subject.keywordPlus | DBC1 | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | SYNTHASE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordAuthor | Colon | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | SIRT1 | - |
dc.subject.keywordAuthor | DBC1 | - |
dc.subject.keywordAuthor | Beta catenin | - |
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