Nestin expression as an indicator of cervical cancer initiation
DC Field | Value | Language |
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dc.contributor.author | Bae, H. S. | - |
dc.contributor.author | Chung, Y. W. | - |
dc.contributor.author | Lee, J. K. | - |
dc.contributor.author | Lee, N. W. | - |
dc.contributor.author | Yeom, B. W. | - |
dc.contributor.author | Lee, K. W. | - |
dc.contributor.author | Song, J. Y. | - |
dc.date.accessioned | 2021-09-06T11:34:34Z | - |
dc.date.available | 2021-09-06T11:34:34Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0392-2936 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106544 | - |
dc.description.abstract | Nestin is an intermediate filament protein expressed in proliferating cells during embryonic development of the central nervous system (CNS) and considered to be a neuronal stem cell/progenitor cell marker. This study investigated the difference of nestin expression between pre-cancer (carcinoma in situ - CIS) and cancer of cervix in 129 tissues (49 normal cervix, 41 CIS, and 39 invasive cervical cancer) through the use of a paraffin-embedded tissue array. Immunostaining was evaluated by intensity, proportion of stained cells, and pattern of expression. The expression of nestin was positive in 63.4% (26/41) for CIS and 43.6% (17/39) for invasive cervical cancer, but only 26.5% (13/49) for normal tissues (p = 0.002). Strong positive staining/large proportion staining were 53.7% (22/41) / 36.6% (15/41), 15.4% (6139) / 61.5% (24/39) in the CIS and invasive cervical cancer tissues, respectively (p = 0.043, p < 0.001). The diffuse stain with basal layer was positive in 90.2% (37/41) for CIS, but only 24.5% (12/49) of the samples were positive in normal tissues (p < 0.001). Based on these results, the authors suggest that nestin expression seems to participate in the step of cancer initiation and could potentially be a useful marker in the early detection of cervical cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | I R O G CANADA, INC | - |
dc.subject | INTERMEDIATE-FILAMENT NESTIN | - |
dc.subject | DIFFERENT TUMORS | - |
dc.subject | CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | P53 | - |
dc.subject | DIAGNOSIS | - |
dc.subject | MARKERS | - |
dc.subject | LESIONS | - |
dc.subject | GRADE | - |
dc.title | Nestin expression as an indicator of cervical cancer initiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, J. Y. | - |
dc.identifier.scopusid | 2-s2.0-84879564875 | - |
dc.identifier.wosid | 000320152200009 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, v.34, no.3, pp.238 - 242 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 238 | - |
dc.citation.endPage | 242 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | INTERMEDIATE-FILAMENT NESTIN | - |
dc.subject.keywordPlus | DIFFERENT TUMORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | GRADE | - |
dc.subject.keywordAuthor | Nestin | - |
dc.subject.keywordAuthor | CIS | - |
dc.subject.keywordAuthor | Cervical cancer | - |
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