Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S. -C. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-06T11:36:45Z | - |
dc.date.available | 2021-09-06T11:36:45Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1676-5680 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106558 | - |
dc.description.abstract | We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were included, encompassing European and Asian studies. Meta-analysis of three European studies showed no significant association between the TLR4 Asp299Gly (rs4986790) polymorphism and rheumatoid arthritis (odds ratio = 0.897, 95% confidence interval = 0.734-1.096, P = 0.289). One Turkish study showed a significant difference between TLR9 rs187084 allele frequencies and rheumatoid arthritis patients and controls, while another study revealed a significant association between rheumatoid factor and TLR8 rs5741883. A Korean study on the numbers of guanine-thymine [(GT)(n)] repeats in intron II of the TLR2 gene found a significantly higher S-allele frequency in rheumatoid arthritis patients than in controls (30.3 vs 23.0%). Overall findings for the meta-analysis including all the studies conclude that TLR polymorphism is associated with development and clinical characteristics of rheumatoid arthritis in Asian and Middle East populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FUNPEC-EDITORA | - |
dc.subject | TOLL-LIKE RECEPTOR-3 | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | TOLL-LIKE-RECEPTOR-4 | - |
dc.subject | THR399ILE | - |
dc.subject | SEVERITY | - |
dc.title | Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.4238/2013.February.7.2 | - |
dc.identifier.scopusid | 2-s2.0-84886752677 | - |
dc.identifier.wosid | 000318864400036 | - |
dc.identifier.bibliographicCitation | GENETICS AND MOLECULAR RESEARCH, v.12, no.1, pp.328 - 334 | - |
dc.relation.isPartOf | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.title | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 328 | - |
dc.citation.endPage | 334 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-3 | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | TOLL-LIKE-RECEPTOR-4 | - |
dc.subject.keywordPlus | THR399ILE | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
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