Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

BLT2 is a pro-tumorigenic mediator during cancer progression and a therapeutic target for anti-cancer drug development

Authors
Cho, Nam-KyuJoo, Young-ChulWei, Jun DongPark, Jae InKim, Jae-Hong
Issue Date
2013
Publisher
E-CENTURY PUBLISHING CORP
Keywords
Leukotriene B-4 receptor 2 (BLT2); leukotriene B-4; NADPH oxidase; reactive oxygen species; nuclear factor-kB; cancer progression
Citation
AMERICAN JOURNAL OF CANCER RESEARCH, v.3, no.4, pp.347 - 355
Journal Title
AMERICAN JOURNAL OF CANCER RESEARCH
Volume
3
Number
4
Start Page
347
End Page
355
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106562
ISSN
2156-6976
Abstract
Cancer is a leading cause of death worldwide and has been linked to inflammation. Leukotriene B-4 (LTB4) is synthesized from arachidonic acid via the 5-lipoxygenase pathway and is a potent chemoattractant for inflammatory cells. LTB4 was recently shown to be associated with the pathogenesis of inflammatory diseases, including cancer. Of the two known LTB4 receptors, BLT1 and BLT2, the biological roles of the low-affinity LTB4 receptor 2, BLT2, have only recently been elucidated. This review focuses on recent discoveries regarding BLT2 and its roles in cancer progression and the downstream signaling mechanisms of the BLT2-linked signaling cascade in cancer cells. We believe that these findings will facilitate the development of new cancer treatments.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jae Hong photo

Kim, Jae Hong
생명과학대학 (생명과학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE