Quantitative Comparison of CDKN2B Methylation in Pediatric and Adult Myelodysplastic Syndromes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Miyoung | - |
dc.contributor.author | Kook, Hoon | - |
dc.contributor.author | Park, Hyeon Jin | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Lee, Kwang Chul | - |
dc.contributor.author | Lee, Kun Soo | - |
dc.contributor.author | Park, Sang Kyu | - |
dc.contributor.author | Lim, Jae Young | - |
dc.contributor.author | Kim, Hyun Kyung | - |
dc.contributor.author | Han, Dong Kyun | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.date.accessioned | 2021-09-06T11:51:03Z | - |
dc.date.available | 2021-09-06T11:51:03Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0001-5792 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106619 | - |
dc.description.abstract | Background/Aims: Transcriptional repression of tumor suppressor genes is determined by the quantity of promoter hypermethylation. We analyzed the methylation quantity of CDKN2B in pediatric myelodysplastic syndromes (MDS). Methods: Quantitative measurement of CDKN2B methylation was performed in 25 pediatric MDS patients and 12 controls using pyrosequencing, and the result was compared with those from 74 adult MDS cases and 31 adult controls. The association between CDKN2B methylation quantity and factors related to prognosis including bone marrow blast percentage and karyotype was analyzed. Resuits: Pediatric MDS patients showed a higher methylation level (MtL) of CDKN2B than pediatric controls (2.94 vs. 1.62; p = 0.031) but a lower level than adult MDS patients (8.76; p < 0.001). MtL was higher in pediatric MDS cases with >5% blasts than in pediatric controls (3.78 vs. 1.62; p = 0.052). Pediatric MDS cases with abnormal karyotype showed a higher MtL than pediatric controls (5.95 vs. 1.62; p = 0.045). Conclusions: We confirmed that nnethylation of CDKN2B is associated with the pathogenesis and prognosis in pediatric MDS. The difference in MtLs between pediatric and adult MDS might be related to the physiological hypermethylation of tumor suppressor genes in aging. Copyright (C) 2013 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | DNA METHYLATION | - |
dc.subject | EPIGENETIC ALTERATIONS | - |
dc.subject | DISEASE PROGRESSION | - |
dc.subject | P15(INK4B) GENE | - |
dc.subject | INSTABILITY | - |
dc.subject | CANCER | - |
dc.subject | P15 | - |
dc.title | Quantitative Comparison of CDKN2B Methylation in Pediatric and Adult Myelodysplastic Syndromes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Chul | - |
dc.identifier.doi | 10.1159/000347038 | - |
dc.identifier.scopusid | 2-s2.0-84875825778 | - |
dc.identifier.wosid | 000323806000011 | - |
dc.identifier.bibliographicCitation | ACTA HAEMATOLOGICA, v.130, no.2, pp.115 - 121 | - |
dc.relation.isPartOf | ACTA HAEMATOLOGICA | - |
dc.citation.title | ACTA HAEMATOLOGICA | - |
dc.citation.volume | 130 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 115 | - |
dc.citation.endPage | 121 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | EPIGENETIC ALTERATIONS | - |
dc.subject.keywordPlus | DISEASE PROGRESSION | - |
dc.subject.keywordPlus | P15(INK4B) GENE | - |
dc.subject.keywordPlus | INSTABILITY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | P15 | - |
dc.subject.keywordAuthor | CDKN2B | - |
dc.subject.keywordAuthor | Methylation | - |
dc.subject.keywordAuthor | Myelodysplasia | - |
dc.subject.keywordAuthor | Pyrosequencing | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.