Growth patterns for acervuli in human pineal gland
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jinkyung | - |
dc.contributor.author | Kim, Hyun-Wook | - |
dc.contributor.author | Chang, Soeun | - |
dc.contributor.author | Kim, Jee Woong | - |
dc.contributor.author | Je, Jung Ho | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.date.accessioned | 2021-09-06T11:56:44Z | - |
dc.date.available | 2021-09-06T11:56:44Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12-17 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106652 | - |
dc.description.abstract | Acervuli are calcified concretions in the pineal gland (PG). Particularly interesting are their incidence and size, which are believed to affect neurological disorders and many physiological functions of PG such as regulating circadian rhythm. Despite long investigations for a century, detailed growth mechanism of acervuli has yet to be studied. Here we study the growth morphology of acervuli in human PGs by a direct visualization in 3-dimension (3-D) using a synchrotron X-ray imaging method. For an entire PG, non-aggregated acervuli show Gaussian distribution in size with 47 +/- 28 mu m. The 3-D volume rendered images of acervuli reveal that the bumpy surfaces developed by lamination result in the mulberry-like structure. In addition, coalescence of multiple acervuli leads to large-scale lamination on the whole aggregate. We suggest a novel hypothesis on the growth patterns of acervuli by their nucleation density (N-d): i) mulberry-like structure at low N-d, and ii) large-scale lamination on an aggregate at high N-d. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ELECTRON-PROBE MICROANALYSIS | - |
dc.subject | MELATONIN BIOSYNTHESIS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | MOUSE MODEL | - |
dc.subject | CALCIFICATION | - |
dc.subject | AGE | - |
dc.subject | CALCIUM | - |
dc.subject | MICROSCOPY | - |
dc.subject | CELLS | - |
dc.title | Growth patterns for acervuli in human pineal gland | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhyu, Im Joo | - |
dc.identifier.doi | 10.1038/srep00984 | - |
dc.identifier.scopusid | 2-s2.0-84871887112 | - |
dc.identifier.wosid | 000312383500002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.2 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ELECTRON-PROBE MICROANALYSIS | - |
dc.subject.keywordPlus | MELATONIN BIOSYNTHESIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | CELLS | - |
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