Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | Lee, Yun Suk | - |
dc.contributor.author | Kim, Hee | - |
dc.contributor.author | Kim, Young-Ho | - |
dc.contributor.author | Roh, Eun Joo | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Shin, Kye Jung | - |
dc.date.accessioned | 2021-09-06T11:57:42Z | - |
dc.date.available | 2021-09-06T11:57:42Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106657 | - |
dc.description.abstract | A series of thiazole derivatives were designed, and prepared to develop RAGE antagonist for the treatment of Alzheimer's disease (AD). SAR studies were performed to optimize inhibitory activity on A beta-RAGE binding. SAR studies showed that introducing an amino group at part A was essential for inhibitory activity on A beta-RAGE binding. Compounds selected from A beta-RAGE binding screening displayed inhibitory activity on A beta transport across BBB. They also showed inhibitory activity against A beta-induced NF-kappa B activation. These results indicated that our derivatives had a potential as therapeutic agent for the treatment of AD. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.identifier.doi | 10.1016/j.bmcl.2012.10.022 | - |
dc.identifier.scopusid | 2-s2.0-84870238175 | - |
dc.identifier.wosid | 000311425500055 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.24, pp.7555 - 7561 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 7555 | - |
dc.citation.endPage | 7561 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | RAGE antagonist | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | beta-Amyloid | - |
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