Associations between the FAS-670 A/G and-1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T12:20:51Z | - |
dc.date.available | 2021-09-06T12:20:51Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106731 | - |
dc.description.abstract | The aim of this study was to explore whether FAS -670 A/G and -1,377 G/A polymorphisms confer susceptibility to autoimmune rheumatic diseases. A meta-analysis was conducted on the associations between the FAS -670 A/G and -1,377 G/A polymorphisms and autoimmune rheumatic diseases using allele contrast, a recessive model, a dominant model, and an additive model. Thirteen articles with 21 comparison studies (16 on FAS -670 A/G and 5 on -1,377 G/A polymorphisms) including systemic lupus erythematosus (SLE), four systemic sclerosis, four Sjogren's syndrome, three rheumatoid arthritis (RA), one juvenile idiopathic arthritis, and one spondyloarthropathy were available for the meta-analysis. Meta-analysis revealed an association between rheumatic diseases and the FAS -670 A/G polymorphism in the dominant model (odds ratio [OR] = 0.761, 95 % confidence interval [CI] = 0.621-0.932, p = 0.008]. Stratification by ethnicity indicated an association between the FAS -670 G allele carrier and rheumatic diseases in Asian (OR = 0.569, 95 % CI = 0.409-0.791, p = 0.001). Furthermore, stratification by disease indicated an association between the FAS -670 G allele carrier and SLE and RA (OR = 0.578, 95 % CI = 0.358-0.934, p = 0.025; OR = 0.609, 95 % CI = 0.398-0.934, p = 0.023, respectively). The FAS -670 G allele was negatively associated with SLE susceptibility. Meta-analysis of the FAS -1,377 G/A polymorphism stratified by disease showed an association between the FAS -1,377 A allele and SLE (OR = 0.783, 95 % CI = 0.613-0.997, p = 0.047). Meta-analyses using the dominant model also showed a significant association in SLE (OR = 0.712, 95 % CI = 0.528-0.961, p = 0.027). This meta-analysis demonstrates that the FAS -670 A/G polymorphism confers susceptibility to rheumatic diseases in Asians and SLE and RA, and the FAS -1,377 G/A polymorphism is associated with SLE susceptibility. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | PRIMARY SJOGRENS-SYNDROME | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | FUNCTIONAL POLYMORPHISM | - |
dc.subject | PROMOTER POLYMORPHISMS | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | FAS | - |
dc.subject | APOPTOSIS | - |
dc.subject | ARTHRITIS | - |
dc.subject | REGION | - |
dc.title | Associations between the FAS-670 A/G and-1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s11033-012-1957-5 | - |
dc.identifier.scopusid | 2-s2.0-85027941155 | - |
dc.identifier.wosid | 000310586700079 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.39, no.12, pp.10671 - 10679 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 39 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 10671 | - |
dc.citation.endPage | 10679 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | PRIMARY SJOGRENS-SYNDROME | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | FUNCTIONAL POLYMORPHISM | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISMS | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | FAS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordAuthor | FAS | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatic diseases | - |
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