Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: Implications on signal transducer and activator of transcription-1 signaling and nitric oxide production
DC Field | Value | Language |
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dc.contributor.author | Park, Ki Hwan | - |
dc.contributor.author | Yoon, Yeo Dae | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.contributor.author | Oh, Soo Jin | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Lee, Chang Woo | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.date.accessioned | 2021-09-06T12:25:29Z | - |
dc.date.available | 2021-09-06T12:25:29Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106751 | - |
dc.description.abstract | Artemisinin is a well-known anti-malarial drug and has been shown to inhibit nitric oxide (NO) production. In this study, we investigated the effect of artemisinin on lipopolysaccharide (LPS)-induced production of IFN-beta and characterized the potential relationship between artemisinin-mediated inhibition of IFN-beta and NO production. Artemisinin suppressed IFN-beta production and mRNA expression in a dose-dependent manner in LPS-stimulated RAW 264.7 cells. LPS-induced phosphorylation of signal transducer and activator of transcription-1 (STAT-1) was also inhibited by artemisinin treatment in RAW 264.7 cells. In addition, artemisinin suppressed LPS-induced production of NO in RAW 264.7 cells. Further study demonstrated that artemisinin-mediated inhibition of NO production and STAT-1 phosphorylation was reversed by addition of exogenous IFN-beta. Moreover, artemisinin does not affect IFN-beta-induced STAT-1 phosphorylation in RAW 264.7 cells. Collectively, these results suggest that the inhibition of IFN-beta production by artemisinin and concomitant attenuation of STAT-1 activation might be involved in artemisinin-mediated inhibition of NO production in macrophages. (c) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | MACROPHAGES | - |
dc.subject | SYNTHASE | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | DERIVATIVES | - |
dc.subject | GENE | - |
dc.subject | SELF | - |
dc.title | Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: Implications on signal transducer and activator of transcription-1 signaling and nitric oxide production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.identifier.doi | 10.1016/j.intimp.2012.09.012 | - |
dc.identifier.scopusid | 2-s2.0-84867607963 | - |
dc.identifier.wosid | 000313152900030 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.14, no.4, pp.580 - 584 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 580 | - |
dc.citation.endPage | 584 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | SYNTHASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SELF | - |
dc.subject.keywordAuthor | Artemisinin | - |
dc.subject.keywordAuthor | IFN-beta | - |
dc.subject.keywordAuthor | STAT-1 | - |
dc.subject.keywordAuthor | Nitric oxide | - |
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