Recovery of pigmentation following selective photothermolysis in adult zebrafish skin: clinical implications for laser toning treatment of melasma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jae Hwan | - |
dc.contributor.author | Kim, Do Hyun | - |
dc.contributor.author | Kim, Ji Hae | - |
dc.contributor.author | Lee, Sang Geun | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Park, Hae Chul | - |
dc.contributor.author | Kim, Il-Hwan | - |
dc.date.accessioned | 2021-09-06T12:26:50Z | - |
dc.date.available | 2021-09-06T12:26:50Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1476-4172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106760 | - |
dc.description.abstract | In recent years, laser toning has gained popularity for the treatment of melasma, and tyrosinase inhibitors are conventionally used to prevent its recurrence after this treatment. The effectiveness of this treatment modality, however, is still questionable, and additional in vivo studies are needed to validate the method. In this study, we used adult zebrafish skin as an adult melanocyte regenerative system and examined the simulated human skin response to laser toning. Melanosomes regenerated after selective photothermolysis, and these organelles showed a bi-directional translocation pattern in accordance with the changes of intact melanosome patterns. Furthermore, a tyrosinase inhibitor, 1-phenyl-2-thiourea (PTU), completely blocked melanosome regeneration after laser irradiation, but this inhibitor failed to prevent melanosome regeneration after the medication was discontinued. Finally, arbutin and kojic acid, the commercially available tyrosinase inhibitors, slowed down but did not completely block melanosome regeneration. Based on these findings, we describe the limitations of laser toning treatment of melasma and the combined use of tyrosinase inhibitors. We suggest that melanosomes in adult zebrafish skin can be utilized for studying melanosome regeneration response to laser irradiation and for developing a system to assess the comparative efficacy of melanogenic regulatory compounds. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS INC | - |
dc.subject | TRIPLE COMBINATION CREAM | - |
dc.subject | ALUMINUM-GARNET LASER | - |
dc.subject | SWITCHED NDYAG LASER | - |
dc.subject | ND/YAG LASER | - |
dc.subject | NEW-MODEL | - |
dc.subject | REGENERATION | - |
dc.subject | MELANOSOMES | - |
dc.subject | MELANOCYTE | - |
dc.subject | TOXICITY | - |
dc.title | Recovery of pigmentation following selective photothermolysis in adult zebrafish skin: clinical implications for laser toning treatment of melasma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Hyeon Soo | - |
dc.contributor.affiliatedAuthor | Park, Hae Chul | - |
dc.contributor.affiliatedAuthor | Kim, Il-Hwan | - |
dc.identifier.doi | 10.3109/14764172.2012.738908 | - |
dc.identifier.scopusid | 2-s2.0-84870844797 | - |
dc.identifier.wosid | 000311897700007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COSMETIC AND LASER THERAPY, v.14, no.6, pp.277 - 285 | - |
dc.relation.isPartOf | JOURNAL OF COSMETIC AND LASER THERAPY | - |
dc.citation.title | JOURNAL OF COSMETIC AND LASER THERAPY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 285 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TRIPLE COMBINATION CREAM | - |
dc.subject.keywordPlus | ALUMINUM-GARNET LASER | - |
dc.subject.keywordPlus | SWITCHED NDYAG LASER | - |
dc.subject.keywordPlus | ND/YAG LASER | - |
dc.subject.keywordPlus | NEW-MODEL | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | MELANOSOMES | - |
dc.subject.keywordPlus | MELANOCYTE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | laser | - |
dc.subject.keywordAuthor | melanosome | - |
dc.subject.keywordAuthor | photothermolysis | - |
dc.subject.keywordAuthor | tyrosinase | - |
dc.subject.keywordAuthor | zebrafish | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.