Synthesis and Biological Evaluation of Low Molecular Weight Fluorescent Imaging Agents for the Prostate-Specific Membrane Antigen
DC Field | Value | Language |
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dc.contributor.author | Chen, Ying | - |
dc.contributor.author | Pullambhatla, Mrudula | - |
dc.contributor.author | Banerjee, Sangeeta R. | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Stathis, Marigo | - |
dc.contributor.author | Rojas, Camilo | - |
dc.contributor.author | Slusher, Barbara S. | - |
dc.contributor.author | Mease, Ronnie C. | - |
dc.contributor.author | Pomper, Martin G. | - |
dc.date.accessioned | 2021-09-06T12:28:15Z | - |
dc.date.available | 2021-09-06T12:28:15Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106769 | - |
dc.description.abstract | Targeted near-infrared (MR) optical imaging can be used in vivo to detect specific tissues, including malignant cells. A series of NIR fluorescent ligands targeting the prostate-specific membrane antigen (PSMA) was synthesized and each compound was tested for its ability to image PSMA+ tissues in experimental models of prostate cancer. The agents were prepared by conjugating commercially available active esters of NIR dyes, including IRDye800CW, IRDye800RS, Cy5.5, Cy7, or a derivative of indocyanine green (ICG) to the terminal amine group of (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido)pentanedioic acid 1, (14S,18S)-1-amino-8,16-dioxo-3,6-dioxa-9,15,17-triazaicosane-14,18,20-tricarboxylic acid 2 and (3S,7S)-26-amino-5,13,20-trioxo-4,6,12,21-tetraaza-hexacosane-1,3,7,22-tetracarboxylic acid 3. The K-i values for the dye-inhibitor conjugates ranged from 1 to 700 pM. All compounds proved capable of imaging PSMA+ tumors selectively to varying degrees depending on the choice of fluorophore and linker. The highest tumor uptake was observed with IRDye800CW employing a poly(ethylene glycol) or lysine suberate linker, as in 800CW-2 and 800CW-3, while the highest tumor to nontarget tissue ratios were obtained for Cy7 with these same linkers, as in Cy7-2 and Cy7-3. Compounds 2 and 3 provide useful scaffolds for targeting of PSMA+ tissues in vivo and should be useful for preparing NIR dye conjugates designed specifically for clinical intraoperative optical imaging devices. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | TUMOR-ASSOCIATED NEOVASCULATURE | - |
dc.subject | GLUTAMATE-CARBOXYPEPTIDASE-II | - |
dc.subject | LINKED ACIDIC DIPEPTIDASE | - |
dc.subject | MONOCLONAL-ANTIBODY J591 | - |
dc.subject | MALIGNANT HUMAN TISSUES | - |
dc.subject | RADICAL PROSTATECTOMY | - |
dc.subject | INDOCYANINE GREEN | - |
dc.subject | CANCER | - |
dc.subject | INHIBITOR | - |
dc.subject | PSMA | - |
dc.title | Synthesis and Biological Evaluation of Low Molecular Weight Fluorescent Imaging Agents for the Prostate-Specific Membrane Antigen | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1021/bc3003919 | - |
dc.identifier.scopusid | 2-s2.0-84871268152 | - |
dc.identifier.wosid | 000312429900007 | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.23, no.12, pp.2377 - 2385 | - |
dc.relation.isPartOf | BIOCONJUGATE CHEMISTRY | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2377 | - |
dc.citation.endPage | 2385 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | TUMOR-ASSOCIATED NEOVASCULATURE | - |
dc.subject.keywordPlus | GLUTAMATE-CARBOXYPEPTIDASE-II | - |
dc.subject.keywordPlus | LINKED ACIDIC DIPEPTIDASE | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY J591 | - |
dc.subject.keywordPlus | MALIGNANT HUMAN TISSUES | - |
dc.subject.keywordPlus | RADICAL PROSTATECTOMY | - |
dc.subject.keywordPlus | INDOCYANINE GREEN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | PSMA | - |
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