Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T12:31:29Z | - |
dc.date.available | 2021-09-06T12:31:29Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106787 | - |
dc.description.abstract | The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma. A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma. Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Meta-analysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR) = 2.257, 95 % confidence interval (CI) = 1.577-3.228, p = 8.42 x 10(-7)]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR = 2.683, 95 % CI = 1.799-4.001, p = 1.31 x 10(-7)), and stratification by age indicated an association between it and asthma in adults (OR = 1.895, 95 % CI = 1.005-3.573, p = 0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms. This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no association was found between the ADAM33 T2 and ST+7 polymorphisms and asthma susceptibility. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | CHINESE HAN POPULATION | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | CHILDHOOD ASTHMA | - |
dc.subject | BRONCHIAL HYPERRESPONSIVENESS | - |
dc.subject | JAPANESE POPULATION | - |
dc.subject | METAANALYSIS | - |
dc.subject | RISK | - |
dc.subject | IDENTIFICATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | DISINTEGRIN | - |
dc.title | Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-012-0536-5 | - |
dc.identifier.scopusid | 2-s2.0-84872176610 | - |
dc.identifier.wosid | 000310995500008 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.61, no.12, pp.1355 - 1362 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 61 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1355 | - |
dc.citation.endPage | 1362 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | CHINESE HAN POPULATION | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | CHILDHOOD ASTHMA | - |
dc.subject.keywordPlus | BRONCHIAL HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | JAPANESE POPULATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DISINTEGRIN | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | ADAM33 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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