Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: an in vitro study of macrophages as a vector for the delivery of gold nanoshells
DC Field | Value | Language |
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dc.contributor.author | Yang, Taeseok Daniel | - |
dc.contributor.author | Choi, Wonshik | - |
dc.contributor.author | Yoon, Tai Hyun | - |
dc.contributor.author | Lee, Kyoung Jin | - |
dc.contributor.author | Lee, Jae-Seung | - |
dc.contributor.author | Han, Sang Hun | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Yim, Hong Soon | - |
dc.contributor.author | Choi, Kyung Min | - |
dc.contributor.author | Park, Min Woo | - |
dc.contributor.author | Jung, Kwang-Yoon | - |
dc.contributor.author | Baek, Seung-Kuk | - |
dc.date.accessioned | 2021-09-06T12:33:10Z | - |
dc.date.available | 2021-09-06T12:33:10Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1083-3668 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106797 | - |
dc.description.abstract | Photothermal treatment (PTT) using nanoparticles has gained attention as a promising alternative therapy for malignant tumors. One strategy for increasing the selectivity of PTT is the use of macrophages as a cellular vector for delivering nanoparticles. The aim of the present study is to examine the use of macrophages as a cellular vector for efficient PTT and determine the appropriate irradiation power and time of a near-infrared (NIR) laser using realtime phase-contrast imaging. Thermally induced injury and death of cancer cells were found to begin at 44 degrees C to 45 degrees C, which was achieved using the PTT effect with gold nanoshells (NS) and irradiation with a NIR laser at a power of 2 W for 5 min. The peritoneal macrophage efficiently functioned as a cellular vector for the NS, and the cancer cells surrounding the NS-loaded macrophages selectively lost their cellular viability after being irradiated with the NIR laser. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.12.128003] | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS | - |
dc.subject | CANCER-CELLS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | THERAPY | - |
dc.subject | TUMORS | - |
dc.subject | INFILTRATION | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | RADIOTHERAPY | - |
dc.subject | ABLATION | - |
dc.subject | BREAST | - |
dc.subject | MODEL | - |
dc.title | Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: an in vitro study of macrophages as a vector for the delivery of gold nanoshells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Tai Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Kyoung Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Seung | - |
dc.contributor.affiliatedAuthor | Jung, Kwang-Yoon | - |
dc.contributor.affiliatedAuthor | Baek, Seung-Kuk | - |
dc.identifier.doi | 10.1117/1.JBO.17.12.128003 | - |
dc.identifier.scopusid | 2-s2.0-84878362058 | - |
dc.identifier.wosid | 000314504400034 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL OPTICS, v.17, no.12 | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.citation.title | JOURNAL OF BIOMEDICAL OPTICS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Optics | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Optics | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | real-time imaging | - |
dc.subject.keywordAuthor | photothermal treatment | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | gold nanoshells | - |
dc.subject.keywordAuthor | squamous cell carcinoma | - |
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