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Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma

Authors
Kang, YoungranJung, Woon YongLee, HyunjooLee, EunjungKim, AereeKim, Baek-hui
Issue Date
12월-2012
Publisher
KOREAN SOCIETY PATHOLOGISTS
Keywords
Stomach; Adenocarcinoma; DBC1 protein, human; SIRT1 protein, human
Citation
KOREAN JOURNAL OF PATHOLOGY, v.46, no.6, pp.523 - 531
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF PATHOLOGY
Volume
46
Number
6
Start Page
523
End Page
531
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106806
DOI
10.4132/KoreanJPathol.2012.46.6.523
ISSN
1738-1843
Abstract
Background: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and beta-catenin and their variable clinicopathological characteristics. Methods: We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed. Results: Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p < 0.001) and pN stage (DBC1, p = 0.002; SIRT1, p < 0.001). Association between absence of lymphatic invasion, and SIRT1 (p = 0.001) and DBC1 (p = 0.004) was observed. Cytoplasmic beta-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p < 0.001),and SIRT1 (p = 0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p = 0.063 and p = 0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p = 0.012). Conclusions: SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.
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