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Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis
- Issue Date
- 12월-2012
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- rhapontigenin; bioconversion; tyrosinase; melanin synthesis inhibition; aglycone
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.76, no.12, pp.2307 - 2309
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 76
- Number
- 12
- Start Page
- 2307
- End Page
- 2309
- ISSN
- 0916-8451
- Abstract
- Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.
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