Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Nyun | - |
dc.contributor.author | Park, Man Sik | - |
dc.contributor.author | Lee, Seong Keon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Lee, Kwan Woo | - |
dc.contributor.author | Nam, Moon Suk | - |
dc.contributor.author | Park, Yong Soo | - |
dc.contributor.author | Woo, Jeong Taek | - |
dc.contributor.author | Kim, Young Seol | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.date.accessioned | 2021-09-06T12:54:07Z | - |
dc.date.available | 2021-09-06T12:54:07Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1355-008x | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106892 | - |
dc.description.abstract | The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) a parts per thousand yen5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG a parts per thousand yen 7.0 mmol/L or 120-min post-challenge plasma glucose a parts per thousand yen11.1 mmol/L or A1C a parts per thousand yen 6.5 %. For insulin sensitivity and beta-cell function classified by the categories of A1C levels, a dagger Ins(30-0)/a dagger Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (a parts per thousand currency sign5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and a dagger Ins(30-0)/a dagger Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with a dagger Ins(30-0)/a dagger Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | ORAL GLUCOSE-TOLERANCE | - |
dc.subject | BETA-CELL FUNCTION | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | FASTING GLUCOSE | - |
dc.subject | HEMOGLOBIN A1C | - |
dc.subject | PLASMA-GLUCOSE | - |
dc.subject | SENSITIVITY | - |
dc.subject | MELLITUS | - |
dc.subject | PROGRESSION | - |
dc.title | Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.identifier.doi | 10.1007/s12020-012-9666-3 | - |
dc.identifier.scopusid | 2-s2.0-84878218220 | - |
dc.identifier.wosid | 000312073500019 | - |
dc.identifier.bibliographicCitation | ENDOCRINE, v.42, no.3, pp.584 - 591 | - |
dc.relation.isPartOf | ENDOCRINE | - |
dc.citation.title | ENDOCRINE | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 584 | - |
dc.citation.endPage | 591 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | ORAL GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | BETA-CELL FUNCTION | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | FASTING GLUCOSE | - |
dc.subject.keywordPlus | HEMOGLOBIN A1C | - |
dc.subject.keywordPlus | PLASMA-GLUCOSE | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | Pre-diabetes | - |
dc.subject.keywordAuthor | Impaired glucose tolerance | - |
dc.subject.keywordAuthor | Impaired fasting glucose | - |
dc.subject.keywordAuthor | Insulinogenic index | - |
dc.subject.keywordAuthor | HOMA-IR | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
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