Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Sook | - |
dc.contributor.author | Park, So-Young | - |
dc.contributor.author | Yoo, Ki-Yeol | - |
dc.contributor.author | Lee, Seung Kwan | - |
dc.contributor.author | Jung, Woon-Won | - |
dc.date.accessioned | 2021-09-06T12:54:26Z | - |
dc.date.available | 2021-09-06T12:54:26Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106894 | - |
dc.description.abstract | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is an environmental toxicant with a polyhalogenated aromatic hydrocarbon structure and is one of the most toxic man-made chemicals. Exposure to 2,3,7,8-TCDD induces reproductive toxicity, immunotoxicity, and hepatotoxicity. In this study, we evaluated how 2,3,7,8-TCDD-induced hepatotoxicity affect the expression of heat shock proteins and antioxidant enzymes using the real-time polymerase chain reaction (PCR) in rat. 2,3,7,8-TCDD increased heat shock protein (Hsp27, alpha-B-crystallin, Mortalin, Hsp105, and Hsp90s) and antioxidant enzymes (SOD-3, GST and catalase) expression after a 1 day exposure in livers of rats, whereas heat shock protein (alpha-B-crystallin, Hsp90, and GRP78) and antioxidant enzymes (SOD-1, SOD-3, catalase, GST, and GPXs) expression decreased on day 2 and then slowly recovered back to control levels on day 8. These results suggest that heat shock proteins and antioxidant enzymes were induced as protective mechanisms against 2,3,7,8-TCDD induced hepatotoxicity, and that prolonged exposure depressed their levels, which recovered to control levels due to reduced 2,3,7,8-TCDD induced hepatotoxicity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.subject | INDUCED OXIDATIVE STRESS | - |
dc.subject | VITAMIN-E SUCCINATE | - |
dc.subject | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | - |
dc.subject | HYDROCARBON RECEPTOR | - |
dc.subject | SUBCHRONIC EXPOSURE | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | DROSOPHILA-MELANOGASTER | - |
dc.subject | PLACENTAL TISSUES | - |
dc.subject | BRAIN-REGIONS | - |
dc.subject | FREE-RADICALS | - |
dc.title | Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Seung Kwan | - |
dc.identifier.doi | 10.4196/kjpp.2012.16.6.469 | - |
dc.identifier.scopusid | 2-s2.0-84876763354 | - |
dc.identifier.wosid | 000312749300014 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.16, no.6, pp.469 - 476 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.citation.volume | 16 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 469 | - |
dc.citation.endPage | 476 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001729769 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | VITAMIN-E SUCCINATE | - |
dc.subject.keywordPlus | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | - |
dc.subject.keywordPlus | HYDROCARBON RECEPTOR | - |
dc.subject.keywordPlus | SUBCHRONIC EXPOSURE | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | PLACENTAL TISSUES | - |
dc.subject.keywordPlus | BRAIN-REGIONS | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordAuthor | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) | - |
dc.subject.keywordAuthor | Antioxidant enzymes | - |
dc.subject.keywordAuthor | Gene expression | - |
dc.subject.keywordAuthor | Heat shock proteins | - |
dc.subject.keywordAuthor | Real-time PCR | - |
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