Disruption of Wave-associated Rac GTPase-activating Protein (Wrp) Leads to Abnormal Adult Neural Progenitor Migration Associated with Hydrocephalus
DC Field | Value | Language |
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dc.contributor.author | Kim, Il Hwan | - |
dc.contributor.author | Carlson, Benjamin R. | - |
dc.contributor.author | Heindel, Clifford C. | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Soderling, Scott H. | - |
dc.date.accessioned | 2021-09-06T13:12:30Z | - |
dc.date.available | 2021-09-06T13:12:30Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-11-09 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106948 | - |
dc.description.abstract | Hydrocephalus is the most common developmental disability and leading cause of brain surgery for children. Current treatments are limited to surgical intervention, as the factors that contribute to the initiation of hydrocephalus are poorly understood. Here, we describe the development of obstructive hydrocephalus in mice that are null for Wrp (Srgap3). Wrp is highly expressed in the ventricular stem cell niche, and it is a gene required for cytoskeletal organization and is associated with syndromic and psychiatric disorders in humans. During the postnatal period of progenitor cell expansion and ventricular wall remodeling, loss of Wrp results in the abnormal migration of lineage-tagged cells from the ventricular region into the corpus callosum. Within this region, mutant progenitors appear to give rise to abnormal astroglial cells and induce periventricular lesions and hemorrhage that leads to cerebral aqueductal occlusion. These results indicate that periventricular abnormalities arising from abnormal migration from the ventricular niche can be an initiating cause of noncommunicating hydrocephalus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject | CHOROID-PLEXUS FUNCTION | - |
dc.subject | F-BAR DOMAIN | - |
dc.subject | STEM-CELLS | - |
dc.subject | NEURONAL MIGRATION | - |
dc.subject | FACTOR RECEPTOR | - |
dc.subject | BRAIN | - |
dc.subject | EXPRESSION | - |
dc.subject | DAMAGE | - |
dc.subject | MICE | - |
dc.title | Disruption of Wave-associated Rac GTPase-activating Protein (Wrp) Leads to Abnormal Adult Neural Progenitor Migration Associated with Hydrocephalus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.identifier.doi | 10.1074/jbc.M112.398834 | - |
dc.identifier.scopusid | 2-s2.0-84869069717 | - |
dc.identifier.wosid | 000310982800081 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.287, no.46, pp.39263 - 39274 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 287 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 39263 | - |
dc.citation.endPage | 39274 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | CHOROID-PLEXUS FUNCTION | - |
dc.subject.keywordPlus | F-BAR DOMAIN | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | NEURONAL MIGRATION | - |
dc.subject.keywordPlus | FACTOR RECEPTOR | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | EPIDERMAL-GROWTH-FACTOR | - |
dc.subject.keywordAuthor | CHOROID-PLEXUS FUNCTION | - |
dc.subject.keywordAuthor | F-BAR DOMAIN | - |
dc.subject.keywordAuthor | STEM-CELLS | - |
dc.subject.keywordAuthor | MOUSE-BRAIN | - |
dc.subject.keywordAuthor | NEURONAL MIGRATION | - |
dc.subject.keywordAuthor | NEUROGENIC NICHE | - |
dc.subject.keywordAuthor | FACTOR RECEPTOR | - |
dc.subject.keywordAuthor | MICE | - |
dc.subject.keywordAuthor | EXPRESSION | - |
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