Blood-pool multifunctional nanoparticles formed by temperature-induced phase transition for cancer-targeting therapy and molecular imaging
- Authors
- Oh, Keun Sang; Lee, Sangmin; Na, Jin Hee; Kim, Jeong-Yeon; Kim, Dong-Eog; Kim, Kwangmeyung; Kwon, Ick Chan; Yuk, Soon Hong; Jeong, Seo Young
- Issue Date
- 1-11월-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Multifunctional nanoparticles; Lipiodol (R); Pluronic F-68; Temperature-induced phase transition; Cancer-targeting therapy; Molecular imaging
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.437, no.1-2, pp.192 - 202
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 437
- Number
- 1-2
- Start Page
- 192
- End Page
- 202
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/106961
- DOI
- 10.1016/j.ijpharm.2012.08.028
- ISSN
- 0378-5173
- Abstract
- Multifunctional nanoparticles (NPs) were prepared based on temperature-induced phase transition in a molten mixture of Lipiodol (R), Tween 80, paclitaxel (PTX), and Pluronic F-68, wherein the Lipiodol (R)/Tween 80 mixture is used as a solubilizer for PTX, and Pluronic F-68 is used for the stabilization of the molten mixture. The morphology and size distribution of optimized multifunctional NPs were observed using transmittance electron microscopy (TEM) and a particle size analyzer. In the optical imaging of tumor-bearing mice using a near-infrared fluorescence (NIRF) imaging system, the multifunctional NPs were evaluated in terms of a time-dependent excretion profile, in vivo biodistribution and tumor-targeting capability compared to free fluorescence dye. In addition, the prolonged circulation of multifunctional NPs was confirmed by enhancement of the blood-pool in live animals using a micro-CT imaging system, because iodine-containing Lipiodol (R) has an X-ray enhancement property. Finally, the anti-tumor efficacy of multifunctional NPs was monitored by injecting the multifunctional NPs into the tail veins of tumor-bearing mice. The multifunctional NPs showed excellent tumor targetability and anti-tumor efficacy in tumor-bearing mice, caused by the enhanced permeation and retention (EPR) effect. (C) 2012 Elsevier B.V. All rights reserved.
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Collections - Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
- College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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