Insight of Key Factors Influencing Tumor Targeting Characteristics of Glycol Chitosan-Based Nanoparticles and In vivo Applications
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2021-09-06T13:37:17Z | - |
dc.date.available | 2021-09-06T13:37:17Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/106994 | - |
dc.description.abstract | Nanoparticles that have been developed to effectively deliver therapeutic drugs and imaging agents to tumor regions could increase therapeutic efficacy while dramatically reducing potential side effects with the capability of diagnosing tumors. In this review article, we discuss the development and optimization processes of glycol chitosan-based polymeric nanoparticles to accomplish the tasks of therapeutic drugs and imaging agents for cancer treatment. To achieve effective tumor imaging and therapy, we optimized the physicochemical properties of nanoparticles and examined several key factors (i.e., molecular weight, stability in the blood, deformability, and rapid cellular uptake), which are important issues influencing the in vivo biodistribution and tumor targeting ability of nanoparticles. Furthermore, we showed their applications in various animal tumor imaging and therapy studies. This review article suggests that the optimization processes for developing novel nanoparticle systems are necessarily required to obtain the most effective therapeutic drugs and imaging agents through in vitro and in vivo studies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject | BEARING 5-BETA-CHOLANIC ACID | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | ANTITUMOR EFFICACY | - |
dc.subject | GENE DELIVERY | - |
dc.subject | DIAGNOSIS | - |
dc.subject | INTERLEUKIN-4 | - |
dc.subject | MICE | - |
dc.subject | BIODISTRIBUTION | - |
dc.title | Insight of Key Factors Influencing Tumor Targeting Characteristics of Glycol Chitosan-Based Nanoparticles and In vivo Applications | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sung Eun | - |
dc.contributor.affiliatedAuthor | Kwon, Ick Chan | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1007/s13233-012-0176-1 | - |
dc.identifier.scopusid | 2-s2.0-84871045020 | - |
dc.identifier.wosid | 000310538900001 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.20, no.11, pp.1109 - 1117 | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 20 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1109 | - |
dc.citation.endPage | 1117 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001712053 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | SELF-ASSEMBLED NANOPARTICLES | - |
dc.subject.keywordPlus | BEARING 5-BETA-CHOLANIC ACID | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | ANTITUMOR EFFICACY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | INTERLEUKIN-4 | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordAuthor | glycol chitosan-based nanoparticles | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | near-infrared fluorescence | - |
dc.subject.keywordAuthor | disease imaging | - |
dc.subject.keywordAuthor | therapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.