Identification of tissue-specific targeting peptide
DC Field | Value | Language |
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dc.contributor.author | Jung, Eunkyoung | - |
dc.contributor.author | Lee, Nam Kyung | - |
dc.contributor.author | Kang, Sang-Kee | - |
dc.contributor.author | Choi, Seung-Hoon | - |
dc.contributor.author | Kim, Daejin | - |
dc.contributor.author | Park, Kisoo | - |
dc.contributor.author | Choi, Kihang | - |
dc.contributor.author | Choi, Yun-Jaie | - |
dc.contributor.author | Jung, Dong Hyun | - |
dc.date.accessioned | 2021-09-06T13:38:46Z | - |
dc.date.available | 2021-09-06T13:38:46Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0920-654X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107003 | - |
dc.description.abstract | Using phage display technique, we identified tissue-targeting peptide sets that recognize specific tissues (bone-marrow dendritic cell, kidney, liver, lung, spleen and visceral adipose tissue). In order to rapidly evaluate tissue-specific targeting peptides, we performed machine learning studies for predicting the tissue-specific targeting activity of peptides on the basis of peptide sequence information using four machine learning models and isolated the groups of peptides capable of mediating selective targeting to specific tissues. As a representative liver-specific targeting sequence, the peptide "DKNLQLH" was selected by the sequence similarity analysis. This peptide has a high degree of homology with protein ligands which can interact with corresponding membrane counterparts. We anticipate that our models will be applicable to the prediction of tissue-specific targeting peptides which can recognize the endothelial markers of target tissues. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ARTIFICIAL NEURAL-NETWORK | - |
dc.subject | VIVO PHAGE DISPLAY | - |
dc.subject | IN-VIVO | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | HOMING PEPTIDE | - |
dc.subject | CELLS | - |
dc.subject | THERAPY | - |
dc.subject | BINDING | - |
dc.subject | LUNG | - |
dc.subject | HETEROGENEITY | - |
dc.title | Identification of tissue-specific targeting peptide | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Kihang | - |
dc.identifier.doi | 10.1007/s10822-012-9614-6 | - |
dc.identifier.wosid | 000311674200006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, v.26, no.11, pp.1267 - 1275 | - |
dc.relation.isPartOf | JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | - |
dc.citation.title | JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | - |
dc.citation.volume | 26 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1267 | - |
dc.citation.endPage | 1275 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Computer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Computer Science, Interdisciplinary Applications | - |
dc.subject.keywordPlus | ARTIFICIAL NEURAL-NETWORK | - |
dc.subject.keywordPlus | VIVO PHAGE DISPLAY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | HOMING PEPTIDE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordAuthor | Machine learning | - |
dc.subject.keywordAuthor | Partial least squares | - |
dc.subject.keywordAuthor | Artificial neural network | - |
dc.subject.keywordAuthor | Bayesian | - |
dc.subject.keywordAuthor | Support vector machine | - |
dc.subject.keywordAuthor | Tissue-specific targeting peptide | - |
dc.subject.keywordAuthor | ROC score | - |
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