Age-dependent changes in the subcallosal zone neurogenesis of mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Kim, Joo Yeon | - |
dc.contributor.author | Sun, Woong | - |
dc.date.accessioned | 2021-09-06T13:55:28Z | - |
dc.date.available | 2021-09-06T13:55:28Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107100 | - |
dc.description.abstract | There are several known neurogenic areas including subventricular zone and subgranular layer in the dentate gyrus of the hippocampus. Both germinal centers exhibit an age-dependent decline in cell proliferation and neurogenesis, which may be associated with age-related decline in brain function. We recently identified the subcallosal zone (SCZ) as a novel neural stem cell niche with a potential to spontaneously produce new neuroblasts. We examined whether SCZ neurogenesis is also regulated by the age of mice. The number of newly generated neuroblasts was reduced in the SCZ with age, and only marginal number of DCX-labeled neuroblasts was found in 6-month-old SCZ, which is most likely due to reduced proliferation of progenitor cells and loss of neural stem cells (NSCs). This age-dependent changes in the SCZ occurred earlier than that of other neurogenic brain regions. The neurosphere assay in vitro confirmed the depletion of NSCs within the SCZ of young adults. However, marked induction of neuroblast production in the SCZ was seen in 6-month-old mice after traumatic brain injury. Taken together, these results indicate that a rapid decline in SCZ neurogenesis in mice is due to depletion of NSCs and reduced capacity to produce neuroblasts. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | NEURAL STEM-CELLS | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | ADULT MAMMALIAN BRAIN | - |
dc.subject | SUBVENTRICULAR ZONE | - |
dc.subject | DENTATE GYRUS | - |
dc.subject | NEURONS | - |
dc.subject | PROLIFERATION | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ORGANIZATION | - |
dc.title | Age-dependent changes in the subcallosal zone neurogenesis of mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.identifier.doi | 10.1016/j.neuint.2012.02.027 | - |
dc.identifier.wosid | 000313374600012 | - |
dc.identifier.bibliographicCitation | NEUROCHEMISTRY INTERNATIONAL, v.61, no.6, pp.879 - 884 | - |
dc.relation.isPartOf | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.title | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.volume | 61 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 879 | - |
dc.citation.endPage | 884 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | ADULT MAMMALIAN BRAIN | - |
dc.subject.keywordPlus | SUBVENTRICULAR ZONE | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Neural stem cell | - |
dc.subject.keywordAuthor | Neurogenesis | - |
dc.subject.keywordAuthor | Traumatic brain injury | - |
dc.subject.keywordAuthor | Subcallosal zone | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.