C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
DC Field | Value | Language |
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dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Hong, Ho Cheol | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Lee, Kwan Woo | - |
dc.contributor.author | Nam, Moon Suk | - |
dc.contributor.author | Park, Yong Soo | - |
dc.contributor.author | Woo, Jeong Taek | - |
dc.contributor.author | Kim, Young Seol | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Youn, Byung-Soo | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.date.accessioned | 2021-09-06T14:00:36Z | - |
dc.date.available | 2021-09-06T14:00:36Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107130 | - |
dc.description.abstract | Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, highsensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors. Diabetes 61:2932-2936, 2012 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | COLLAGENOUS REPEAT | - |
dc.subject | ADIPOKINE | - |
dc.subject | GENE | - |
dc.subject | CTRP3/CARTDUCIN | - |
dc.subject | PROLIFERATION | - |
dc.subject | SEQUENCE | - |
dc.subject | LEVEL | - |
dc.subject | FAT | - |
dc.title | C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Hwang, Soon Young | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.identifier.doi | 10.2337/db12-0217 | - |
dc.identifier.scopusid | 2-s2.0-84868016394 | - |
dc.identifier.wosid | 000312041600031 | - |
dc.identifier.bibliographicCitation | DIABETES, v.61, no.11, pp.2932 - 2936 | - |
dc.relation.isPartOf | DIABETES | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 61 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2932 | - |
dc.citation.endPage | 2936 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | COLLAGENOUS REPEAT | - |
dc.subject.keywordPlus | ADIPOKINE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CTRP3/CARTDUCIN | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordPlus | FAT | - |
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