Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eun, So-Hee | - |
dc.contributor.author | Eun, Baik-Lin | - |
dc.contributor.author | Lee, Joon Soo | - |
dc.contributor.author | Hwang, Yong Seung | - |
dc.contributor.author | Kim, Ki Joong | - |
dc.contributor.author | Lee, Young-Mock | - |
dc.contributor.author | Lee, In Goo | - |
dc.contributor.author | Lee, Munhyang | - |
dc.contributor.author | Ko, Tae-Sung | - |
dc.contributor.author | Kim, Jeong Tae | - |
dc.contributor.author | Eom, Soyong | - |
dc.contributor.author | Kim, Heung Dong | - |
dc.date.accessioned | 2021-09-06T14:01:30Z | - |
dc.date.available | 2021-09-06T14:01:30Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0387-7604 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107135 | - |
dc.description.abstract | To compare the cognitive and behavioral effects of lamotrigine (LTG) to carbamazepine (CBZ) as monotherapy for pediatric epilepsy. A multicenter, randomized, open-label, parallel-group clinical trial was conducted in children with partial-onset seizures. LTG or CBZ was prescribed as monotherapy for previously untreated children and titrated over 8 weeks, followed by maintenance for 24 weeks. Outcome measures were change in cognition and behavior in a combined analysis of standardized measures from screening to the end of the maintenance phase, as well as antiepileptic efficacy and tolerability. A total of 67 children completed the study, including 32 of 43 (74.4%) treated with LTG and 35 of 41(85.4%) treated with CBZ. Seizure-free outcomes did not differ between the intent-to-treat populations (53.5% LTG, 56.1% CBZ; p = 0.81). There were no statistically significant differences in the intelligence of the two groups after treatment. Externalizing behavior problems improved in the CBZ group (p < 0.05). However, there were no significant differences between the two groups in terms of externalizing behavior. The parents' report on the Conner scale showed an improvement in the CBZ group compared to the LTG group (p < 0.05). LTG and CBZ showed similar efficacy and cognitive effects in treating childhood partial epilepsy. However, CBZ showed more benefits in improving externalizing behaviors. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | MULTICENTER | - |
dc.subject | TRIAL | - |
dc.title | Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Eun, So-Hee | - |
dc.contributor.affiliatedAuthor | Eun, Baik-Lin | - |
dc.identifier.doi | 10.1016/j.braindev.2012.03.006 | - |
dc.identifier.scopusid | 2-s2.0-84867720212 | - |
dc.identifier.wosid | 000311466000004 | - |
dc.identifier.bibliographicCitation | BRAIN & DEVELOPMENT, v.34, no.10, pp.818 - 823 | - |
dc.relation.isPartOf | BRAIN & DEVELOPMENT | - |
dc.citation.title | BRAIN & DEVELOPMENT | - |
dc.citation.volume | 34 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 818 | - |
dc.citation.endPage | 823 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Lamotrigine | - |
dc.subject.keywordAuthor | Cognition | - |
dc.subject.keywordAuthor | Behavior | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Partial epilepsy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.