Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway
- Authors
- Yoon, Ki-Jun; Lee, Hye-Ryeon; Jo, Yong Sang; An, Kyongman; Jung, Sang-Yong; Jeong, Min-Woo; Kwon, Seok-Kyu; Kim, Nam-Shik; Jeong, Hyun-Woo; Ahn, Seo-Hee; Kim, Kyong-Tai; Lee, Kyungmin; Kim, Eunjoon; Kim, Joung-Hun; Choi, June-Seek; Kaang, Bong-Kiun; Kong, Young-Yun
- Issue Date
- 30-10월-2012
- Publisher
- BMC
- Keywords
- Mind bomb-1; Notch; Synaptic plasticity; Memory; Hippocampus
- Citation
- MOLECULAR BRAIN, v.5
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BRAIN
- Volume
- 5
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107173
- DOI
- 10.1186/1756-6606-5-40
- ISSN
- 1756-6606
- Abstract
- Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.
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