Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Han-Na | - |
dc.contributor.author | Park, Soo-Hyun | - |
dc.contributor.author | Lee, Eun-Kyung | - |
dc.contributor.author | Bernardo, Raymundo | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.date.accessioned | 2021-09-06T14:30:04Z | - |
dc.date.available | 2021-09-06T14:30:04Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-10-12 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107213 | - |
dc.description.abstract | Recent reports have suggested that tumors are organized in heterogeneous populations. Within these populations, a small subpopulation of cells is more capable of initiating malignancy; these are called cancer stem cells. In this study, HT-29 cells were sorted according to the presence or absence of the cancer stem cell marker CD133. We confirmed that CD133+ cells possessed higher clonogenicity compared to CD133- cells. Furthermore, proteomic analysis identified 10 proteins, including actin-related protein 2/3 complex subunit 5-like and profilin 2. In conclusion, our data demonstrated that the expression of specific proteins associated with metastasis and invasion in CD133+ cells contributed to the sternness and tumorigenic properties of these cells. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | HEPATOCELLULAR-CARCINOMA CELLS | - |
dc.subject | STEM-CELLS | - |
dc.subject | ARP2/3 COMPLEX | - |
dc.subject | IDENTIFICATION | - |
dc.subject | PROTEIN | - |
dc.subject | SUBPOPULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | PREFOLDIN | - |
dc.subject | BINDING | - |
dc.subject | MODEL | - |
dc.title | Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.09.036 | - |
dc.identifier.scopusid | 2-s2.0-84867646822 | - |
dc.identifier.wosid | 000310651300030 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.427, no.1, pp.171 - 177 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 427 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 177 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA CELLS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | ARP2/3 COMPLEX | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SUBPOPULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PREFOLDIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Cancer stem cell | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
dc.subject.keywordAuthor | CD133 | - |
dc.subject.keywordAuthor | Two dimensional gel electrophoresis | - |
dc.subject.keywordAuthor | Proteomics | - |
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