Geno-Tox: Cell Array Biochip for Genotoxicity Monitoring and Classification
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Joo-Myung | - |
dc.contributor.author | Gu, Man Bock | - |
dc.date.accessioned | 2021-09-06T14:46:39Z | - |
dc.date.available | 2021-09-06T14:46:39Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107257 | - |
dc.description.abstract | In vitro genotoxicity tests detect carcinogens that are thought to act primarily via a mechanism involving direct genetic damage. In this study, we constructed a Geno-Tox cell array chip for genotoxicity testing; eight recombinant bioluminescent bacteria were used to successfully fabricate a Geno-Tox cell array chip. Four well-characterized DNA damage chemicals were selected to determine the capabilities of this Geno-Tox array chip, and each strain of the chip was distinctly responsive, according to the specific mode of genotoxic action. Therefore, this Geno-Tox cell array chip could be implemented to characterize and understand the genotoxic modes of impact; thus, it could be used to provide the genotoxic mechanism of action for new drugs or unknown or newly synthesized chemicals in food and the environment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | HUMANA PRESS INC | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | TOXICITY ANALYSIS | - |
dc.subject | COMET ASSAY | - |
dc.subject | BIOSENSOR | - |
dc.subject | CARCINOGENICITY | - |
dc.subject | CHEMICALS | - |
dc.subject | FUSION | - |
dc.subject | RECA | - |
dc.title | Geno-Tox: Cell Array Biochip for Genotoxicity Monitoring and Classification | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Gu, Man Bock | - |
dc.identifier.doi | 10.1007/s12010-012-9815-4 | - |
dc.identifier.scopusid | 2-s2.0-84869123720 | - |
dc.identifier.wosid | 000309870500003 | - |
dc.identifier.bibliographicCitation | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, v.168, no.4, pp.752 - 760 | - |
dc.relation.isPartOf | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.citation.title | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.citation.volume | 168 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 752 | - |
dc.citation.endPage | 760 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | TOXICITY ANALYSIS | - |
dc.subject.keywordPlus | COMET ASSAY | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | CARCINOGENICITY | - |
dc.subject.keywordPlus | CHEMICALS | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | RECA | - |
dc.subject.keywordAuthor | DNA damage response | - |
dc.subject.keywordAuthor | Bioluminescence bacteria | - |
dc.subject.keywordAuthor | Cell array biochip | - |
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