Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: A meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 10월-2012
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- GENOME-WIDE ASSOCIATION; HUMAN OX40 LIGAND; SUSCEPTIBILITY LOCI; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASES; T-CELLS; IDENTIFICATION; SUPERFAMILY; COMPLEMENT; RECEPTORS
- Citation
- HUMAN IMMUNOLOGY, v.73, no.10, pp.1050 - 1054
- Indexed
- SCIE
SCOPUS
- Journal Title
- HUMAN IMMUNOLOGY
- Volume
- 73
- Number
- 10
- Start Page
- 1050
- End Page
- 1054
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107282
- DOI
- 10.1016/j.humimm.2012.07.044
- ISSN
- 0198-8859
- Abstract
- Objective: The aim of this study was to determine whether tumor necrosis factor superfamily 4 (TNFSF4) and TNF receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: The authors conducted meta-analyses on associations between polymorphisms of the TNFSF4 (rs2205960, rs1234315, rs10489265) and TRAF1-C5 (rs10818488, rs3761847) genes and SLE susceptibility, using fixed and random effects models. Results: A total of 21 comparative studies were included in this meta-analysis; meta-analysis showed an association between the minor allele of rs2205960 of TNFSF4 and SLE in all study subjects (odds ratio [OR] = 1.356, 95% confidence interval [CI] = 1.275-1.442, p < 1.0 x 10(-9)). Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR = 1.366. 95% CI = 1.295-1.440, p< 1.0 x 10(-9); OR= 1.463, 95% CI = 1.208-1.771, p = 9.7 x 10(-5)). The minor allele of rs10818488 of TRAF1-C5 was found to be significantly associated with SLE in Europeans (OR = 1.210, 95% CI = 1.115-1.313, p = 5.0 x 10(-6)). The association p-values remained significant after multiple corrections. Conclusions: This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans. An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to SLE in Europeans. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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