Extremely low-frequency magnetic fields modulate nitric oxide signaling in rat brain
- Authors
- Cho, Sung In; Nam, Yun Sung; Chu, Li Ying; Lee, Jong Hyuk; Bang, Joon Seok; Kim, Hye Ryoun; Kim, Hyoung-Chun; Lee, Yu Jeung; Kim, Hyeong-Dong; Sul, Jung Duk; Kim, Daejin; Chung, Yoon Hee; Jeong, Ji Hoon
- Issue Date
- 10월-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- extremely low frequency magnetic field (ELF-MF); nitric oxide; NO synthase; brain; immunohistochemistry
- Citation
- BIOELECTROMAGNETICS, v.33, no.7, pp.568 - 574
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOELECTROMAGNETICS
- Volume
- 33
- Number
- 7
- Start Page
- 568
- End Page
- 574
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107329
- DOI
- 10.1002/bem.21715
- ISSN
- 0197-8462
- Abstract
- Our previous study has shown that an extremely low-frequency magnetic field (ELF-MF) induces nitric oxide (NO) synthesis by Ca2+-dependent NO synthase (NOS) in rat brain. The present study was designed to confirm that ELF-MF affects neuronal NOS (nNOS) in several brain regions and to investigate the correlation between NO and nNOS activation. The exposure of rats to a 2?mT, 60?Hz ELF-MF for 5 days resulted in increases of NO levels in parallel with cGMP elevations in the cerebral cortex, striatum, and hippocampus. Cresyl violet staining and electron microscopic evaluation revealed that there were no significant differences in the morphology and number of neurons in the cerebral cortex, striatum, and hippocampus. Differently, the numbers of nNOS-immunoreactive (IR) neurons were significantly increased in those cerebral areas in ELF-MF-exposed rats. These data suggest that the increase in NO could be due to the increased expression and activation of nNOS in cells. Based on NO signaling in physiological and pathological states, ELF-MF created by electric power systems may induce various physiological changes in modern life. Bioelectromagnetics 33:568574, 2012. (c) 2012 Wiley Periodicals, Inc.
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Collections - College of Health Sciences > School of Health and Environmental Science > 1. Journal Articles
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