Association between-276 C/T Polymorphism of the ERBB3 Gene and Lung Cancer Risk in a Korean Population
DC Field | Value | Language |
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dc.contributor.author | Sung, Jae Sook | - |
dc.contributor.author | Jin, Lihua | - |
dc.contributor.author | Jo, Ukhyun | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.date.accessioned | 2021-09-06T15:03:01Z | - |
dc.date.available | 2021-09-06T15:03:01Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107353 | - |
dc.description.abstract | Background/Aim: The associations between the polymorphisms in the promoter region of the V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) gene and lung cancer risk were investigated. Materials and Methods: By direct sequencing, we first found two known polymorphisms (-536 A/G and -276 C/T. Further TaqMan assays and logistic regression analyses were performed in order to characterize the association between the -276 C/T polymorphism of ERBB3 and lung cancer risk in 425 patients with lung cancer and 411 healthy controls. To examine the potential effects of the -276 C/T polymorphism on ERBB3 transcription, luciferase reporter assays were performed in non-small cell lung cancer (NSCLC) cell lines. Results: The -276 C/T polymorphism was associated with the risk of lung cancer in a recessive model of never-smokers. Interestingly, the T allele conferred significantly lower promoter activity by 32% and 33% than the C allele in H2009 and H358 cell lines. Conclusion: ERBB3 promoter polymorphisms affect ERBB3 gene expression, and contribute to genetic susceptibility to lung cancer in never-smokers. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.subject | C-ERBB-3 PROTEIN EXPRESSION | - |
dc.subject | FACTOR RECEPTOR FAMILY | - |
dc.subject | SOMATIC MUTATIONS | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | SURVIVAL | - |
dc.title | Association between-276 C/T Polymorphism of the ERBB3 Gene and Lung Cancer Risk in a Korean Population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Jae Sook | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.scopusid | 2-s2.0-84867763362 | - |
dc.identifier.wosid | 000310111800032 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.32, no.10, pp.4433 - 4437 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4433 | - |
dc.citation.endPage | 4437 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | C-ERBB-3 PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | FACTOR RECEPTOR FAMILY | - |
dc.subject.keywordPlus | SOMATIC MUTATIONS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | ERBB3 gene | - |
dc.subject.keywordAuthor | -276 C/T polymorphism | - |
dc.subject.keywordAuthor | Korean population | - |
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