DIFFERENT EXPRESSION PATTERNS OF PHACTR FAMILY MEMBERS IN NORMAL AND INJURED MOUSE BRAIN
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. Y. | - |
dc.contributor.author | Choi, S. Y. | - |
dc.contributor.author | Moon, Y. | - |
dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Chin, J. H. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Sun, W. | - |
dc.date.accessioned | 2021-09-06T15:16:42Z | - |
dc.date.available | 2021-09-06T15:16:42Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2012-09-27 | - |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107432 | - |
dc.description.abstract | Phosphatase and actin regulators (Phactrs) are a novel family of proteins expressed in the brain, and they exhibit both strong modulatory activity of protein phosphatase 1 and actin-binding activity. Phactrs are comprised of four family members (Phactr1-4), but their detailed expression patterns during embryonic and postnatal development are not well understood. We found that these family members exhibit different spatiotemporal mRNA expression patterns. Phactr4 mRNA was found in neural stem cells in the developing and adult brains, whereas Phactr1 and 3 appeared to be expressed in post-mitotic neurons. Following traumatic brain injury which promotes neurogenesis in the neurogenic region and gliogenesis in the injury penumbra, the mRNA expression of phactr2 and 4 was progressively increased in the injury penumbra, and phactr4 mRNA and protein induction was observed in reactive astrocytes. These differential expression patterns of phactrs imply specific functions for each protein during development, and the importance of Phactr4 in the reactive gliosis following brain injury. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROTEIN PHOSPHATASE 1 | - |
dc.subject | PROGRAMMED CELL-DEATH | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | NEURAL STEM-CELLS | - |
dc.subject | REACTIVE ASTROCYTES | - |
dc.subject | HIPPOCAMPAL CONTINUATION | - |
dc.subject | INDUSIUM GRISEUM | - |
dc.subject | ADULT BRAIN | - |
dc.subject | GLIOSIS | - |
dc.subject | RAT | - |
dc.title | DIFFERENT EXPRESSION PATTERNS OF PHACTR FAMILY MEMBERS IN NORMAL AND INJURED MOUSE BRAIN | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, H. | - |
dc.contributor.affiliatedAuthor | Sun, W. | - |
dc.identifier.doi | 10.1016/j.neuroscience.2012.06.059 | - |
dc.identifier.scopusid | 2-s2.0-84864360262 | - |
dc.identifier.wosid | 000308628100005 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE, v.221, pp.37 - 46 | - |
dc.relation.isPartOf | NEUROSCIENCE | - |
dc.citation.title | NEUROSCIENCE | - |
dc.citation.volume | 221 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 46 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE 1 | - |
dc.subject.keywordPlus | PROGRAMMED CELL-DEATH | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | REACTIVE ASTROCYTES | - |
dc.subject.keywordPlus | HIPPOCAMPAL CONTINUATION | - |
dc.subject.keywordPlus | INDUSIUM GRISEUM | - |
dc.subject.keywordPlus | ADULT BRAIN | - |
dc.subject.keywordPlus | GLIOSIS | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | Phactrs | - |
dc.subject.keywordAuthor | neural stem/progenitor cell | - |
dc.subject.keywordAuthor | traumatic brain injury | - |
dc.subject.keywordAuthor | in situ hybridization | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.