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Design, Synthesis, and Preliminary Cytotoxicity Evaluation of New Diarylureas and Diarylamides Possessing 1,3,4-Triarylpyrazole Scaffold
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Choi, Won-Kyoung | - |
| dc.contributor.author | El-Gamal, Mohammed I. | - |
| dc.contributor.author | Choi, Hong Seok | - |
| dc.contributor.author | Hong, Jun Hee | - |
| dc.contributor.author | Baek, Daejin | - |
| dc.contributor.author | Choi, Kihang | - |
| dc.contributor.author | Oh, Chang-Hyun | - |
| dc.date.accessioned | 2021-09-06T15:25:43Z | - |
| dc.date.available | 2021-09-06T15:25:43Z | - |
| dc.date.created | 2021-06-18 | - |
| dc.date.issued | 2012-09-20 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107448 | - |
| dc.description.abstract | A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | KOREAN CHEMICAL SOC | - |
| dc.subject | MELANOMA-CELL LINE | - |
| dc.subject | ANTIPROLIFERATIVE ACTIVITY | - |
| dc.subject | DERIVATIVES | - |
| dc.subject | DISCOVERY | - |
| dc.title | Design, Synthesis, and Preliminary Cytotoxicity Evaluation of New Diarylureas and Diarylamides Possessing 1,3,4-Triarylpyrazole Scaffold | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Choi, Kihang | - |
| dc.identifier.doi | 10.5012/bkcs.2012.33.9.2991 | - |
| dc.identifier.scopusid | 2-s2.0-84866406828 | - |
| dc.identifier.wosid | 000309307400031 | - |
| dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.9, pp.2991 - 2998 | - |
| dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.volume | 33 | - |
| dc.citation.number | 9 | - |
| dc.citation.startPage | 2991 | - |
| dc.citation.endPage | 2998 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001695312 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | MELANOMA-CELL LINE | - |
| dc.subject.keywordPlus | ANTIPROLIFERATIVE ACTIVITY | - |
| dc.subject.keywordPlus | DERIVATIVES | - |
| dc.subject.keywordPlus | DISCOVERY | - |
| dc.subject.keywordAuthor | A375P | - |
| dc.subject.keywordAuthor | Anticancer | - |
| dc.subject.keywordAuthor | Diarylamide | - |
| dc.subject.keywordAuthor | Diarylurea | - |
| dc.subject.keywordAuthor | 1,3,4-Triarylpyrazole | - |
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Related Researcher
- CHOI, Ki hang
- College of Science (Department of Chemistry)