Expression of estrogen receptors in gastric cancer and their clinical significance
DC Field | Value | Language |
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dc.contributor.author | Ryu, Woo-Sang | - |
dc.contributor.author | Kim, Jong-Han | - |
dc.contributor.author | Jang, You-Jin | - |
dc.contributor.author | Park, Sung-Soo | - |
dc.contributor.author | Um, Jun-Won | - |
dc.contributor.author | Park, Seong-Heum | - |
dc.contributor.author | Kim, Seung-Joo | - |
dc.contributor.author | Mok, Young-Jae | - |
dc.contributor.author | Kim, Chong-Suk | - |
dc.date.accessioned | 2021-09-06T15:49:56Z | - |
dc.date.available | 2021-09-06T15:49:56Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107489 | - |
dc.description.abstract | Backgrounds and Objectives The male predominance of gastric cancer suggests that female sex hormones may have a protective effect against gastric cancer. We evaluated the expression of estrogen receptors in gastric cancer tissue and cells and the clinical significance of ER-beta expression in gastric cancer. Method ER-alpha, ER-beta proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO-III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis. The clinical significance of ER-beta was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers. Results Both ER-alpha and beta protein expression were noted in normal and gastric cancer tissues. However, in cultured gastric cells, only ER-beta was noted in mkn28 and mkn74. Of 148 gastric cancers, 67 (45.3%) were ER-beta positive. The ER-beta positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence. The ER-beta positive group had a better 3-year survival compared with the negative group in survival analysis. Conclusion Our results suggest that the presence of ER-beta in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER-beta in gastric cancers. J. Surg. Oncol. 2012; 106:456461. (c) 2012 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TAMOXIFEN EXPOSURE | - |
dc.subject | PROSTATE-CANCER | - |
dc.subject | SEX-HORMONES | - |
dc.subject | CELL-LINES | - |
dc.subject | ER-BETA | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | ALPHA | - |
dc.subject | RISK | - |
dc.subject | IMMUNOLOCALIZATION | - |
dc.subject | CARCINOGENESIS | - |
dc.title | Expression of estrogen receptors in gastric cancer and their clinical significance | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Han | - |
dc.contributor.affiliatedAuthor | Jang, You-Jin | - |
dc.contributor.affiliatedAuthor | Park, Sung-Soo | - |
dc.contributor.affiliatedAuthor | Um, Jun-Won | - |
dc.contributor.affiliatedAuthor | Park, Seong-Heum | - |
dc.contributor.affiliatedAuthor | Kim, Seung-Joo | - |
dc.contributor.affiliatedAuthor | Mok, Young-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Chong-Suk | - |
dc.identifier.doi | 10.1002/jso.23097 | - |
dc.identifier.scopusid | 2-s2.0-84865121899 | - |
dc.identifier.wosid | 000307550900017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, v.106, no.4, pp.456 - 461 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.citation.title | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.citation.volume | 106 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 456 | - |
dc.citation.endPage | 461 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TAMOXIFEN EXPOSURE | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | SEX-HORMONES | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | ER-BETA | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | IMMUNOLOCALIZATION | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordAuthor | estrogen receptor a | - |
dc.subject.keywordAuthor | estrogen receptor ss | - |
dc.subject.keywordAuthor | gastric cancer | - |
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