Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwag, Jeehyun | - |
dc.contributor.author | Paulsen, Ole | - |
dc.date.accessioned | 2021-09-06T16:00:39Z | - |
dc.date.available | 2021-09-06T16:00:39Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0028-3908 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107551 | - |
dc.description.abstract | Hippocampal long-term potentiation (LIP) is believed to be important for learning and memory. Experimentally, the pairing of precisely timed pre- and postsynaptic spikes within a time window of similar to 10 ms can induce timing-dependent LIP (tLTP), but the requirements for induction of tLTP change with development: in young rodents single postsynaptic spikes are sufficient to induce tLTP, whereas postsynaptic burst firing appears to be required in the adult. However, hippocampal neurons in vivo show theta-modulated single spike activities also in older hippocampus. Here we investigated the conditions for single spike pairing to induce tLTP at older CA3-CA1 synapses. We found that the pairing of single pre- and postsynaptic spikes could induce tLTP in older hippocampus when the postsynaptic neuronal membrane was depolarized and the pairing frequency exceeded similar to 4 Hz. The spike frequency requirement is postsynaptic, as tLTP could still be induced with presynaptic stimulation at 1 Hz as long as the postsynaptic spike frequency exceeded similar to 4 Hz, suggesting that postsynaptic theta-frequency activity is required for the successful induction of tLTP at older CA3-CA1 synapses. The induction of tLTP was blocked by an NMDA receptor antagonist and by the selective mGluR5 blockers, MPEP and MTEP, whereas activation of mGluR1 and mGluR5 by DHPG relieved the postsynaptic spike frequency requirement for tLTP induction. These results suggest that activation of mGluR5 during single-spike pairing at older CA3-CA1 synapses gates NMDA receptor-dependent tLTP. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | CA1 PYRAMIDAL NEURONS | - |
dc.subject | FREELY MOVING RATS | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | AREA CA1 | - |
dc.subject | PROTEIN-SYNTHESIS | - |
dc.subject | POSTSYNAPTIC INDUCTION | - |
dc.subject | PRESYNAPTIC EXPRESSION | - |
dc.subject | CELL EXCITABILITY | - |
dc.title | Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwag, Jeehyun | - |
dc.identifier.doi | 10.1016/j.neuropharm.2012.05.021 | - |
dc.identifier.scopusid | 2-s2.0-84863626489 | - |
dc.identifier.wosid | 000306637700022 | - |
dc.identifier.bibliographicCitation | NEUROPHARMACOLOGY, v.63, no.4, pp.701 - 709 | - |
dc.relation.isPartOf | NEUROPHARMACOLOGY | - |
dc.citation.title | NEUROPHARMACOLOGY | - |
dc.citation.volume | 63 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 701 | - |
dc.citation.endPage | 709 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | CA1 PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | FREELY MOVING RATS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | AREA CA1 | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | POSTSYNAPTIC INDUCTION | - |
dc.subject.keywordPlus | PRESYNAPTIC EXPRESSION | - |
dc.subject.keywordPlus | CELL EXCITABILITY | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | mGluR5 | - |
dc.subject.keywordAuthor | Spike timing-dependent plasticity | - |
dc.subject.keywordAuthor | CA1 | - |
dc.subject.keywordAuthor | Development | - |
dc.subject.keywordAuthor | Rat | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.