Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy

Abstract

Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time.