N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyereen | - |
dc.contributor.author | Lee, Minjae | - |
dc.contributor.author | Choi, Kyung-chul | - |
dc.contributor.author | Shin, Dong-Myoung | - |
dc.contributor.author | Ko, Jesang | - |
dc.contributor.author | Jang, Sung-Wuk | - |
dc.date.accessioned | 2021-09-06T16:07:49Z | - |
dc.date.available | 2021-09-06T16:07:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107592 | - |
dc.description.abstract | Synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been reported to exhibit anti-invasive and anti-metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)-9, but the underlying mechanism remains unclear. Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. 4-HPR inhibits the transcriptional activity of MMP-9 by reducing the DNA-binding activity of NF-?B on the MMP-9 promoter as well as by inhibiting the degradation of I?Ba, leading to cytoplasmic accumulation of NF-?B. We also found that 4-HPR inhibits invasion and MMP-9 expression in the highly metastatic breast cancer cell line MDA-MB-231. Thus, 4-HPR might be a potent anti-invasive agent that works by suppressing MMP-9 expression via the NF-?B signaling pathway. J. Cell. Biochem. 113: 28452855, 2012. (C) 2012 Wiley Periodicals, Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | CONSTITUTIVE ACTIVATION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | APOPTOSIS | - |
dc.subject | RETINOIDS | - |
dc.subject | PROSTATE | - |
dc.subject | THERAPY | - |
dc.subject | PROGRESSION | - |
dc.title | N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.1002/jcb.24159 | - |
dc.identifier.scopusid | 2-s2.0-84863643540 | - |
dc.identifier.wosid | 000306292700006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.9, pp.2845 - 2855 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.title | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.volume | 113 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2845 | - |
dc.citation.endPage | 2855 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | CONSTITUTIVE ACTIVATION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RETINOIDS | - |
dc.subject.keywordPlus | PROSTATE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordAuthor | 4-HPR | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | CELL INVASION | - |
dc.subject.keywordAuthor | NF-?B | - |
dc.subject.keywordAuthor | BREAST CANCER | - |
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