Protective effect of NecroX, a novel necroptosis inhibitor, on gentamicin-induced ototoxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Moo Kyun | - |
dc.contributor.author | Lee, Byung Don | - |
dc.contributor.author | Chae, Sung Won | - |
dc.contributor.author | Chi, Junhyuk | - |
dc.contributor.author | Kwon, Seong Keun | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2021-09-06T16:13:46Z | - |
dc.date.available | 2021-09-06T16:13:46Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0165-5876 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107627 | - |
dc.description.abstract | Introduction: NecroX is a novel necrosis and necroptosis inhibitor that shows scavenger activity against mitochondrial reactive oxygen species (ROS) and cytoprotective activity against various insults. These findings raise the possibility of its protective effect in ototoxicity. This study was performed to investigate the protective effect of NecroX on gentamicin (GM)-induced hair cell loss in neonatal mouse cochlea cultures. Materials and methods: The protective effects of NecroX were measured by phalloidin staining of cultures from postnatal day 2-3 mice with GM-induced hair cell loss. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was used to detect apoptosis. The radical-scavenging activity of NecroX was assessed using the 1,1-dipheny1-2-picrylhydrazyl (DPPH) assay. Results: NecroX showed a significant and concentration-dependent protective effect against GM-induced hair cell loss, and hair cells retained their stereocilia well. NecroX decreased GM-induced apoptosis of hair cells as assessed by TUNEL staining. Additionally, NecroX showed direct radical scavenging activity in the DPPH assay. Conclusions: In this study, we demonstrated the protective effect of NecroX on GM-induced hair cell loss in neonatal cochlea cultures, and suggest that it may be of therapeutic use in the treatment of druginduced ototoxicity. (c) 2012 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | INDUCED HEARING-LOSS | - |
dc.subject | COCHLEAR | - |
dc.subject | INJURY | - |
dc.title | Protective effect of NecroX, a novel necroptosis inhibitor, on gentamicin-induced ototoxicity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chae, Sung Won | - |
dc.identifier.doi | 10.1016/j.ijporl.2012.05.016 | - |
dc.identifier.scopusid | 2-s2.0-84865361783 | - |
dc.identifier.wosid | 000309033300007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, v.76, no.9, pp.1265 - 1269 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | - |
dc.citation.volume | 76 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1265 | - |
dc.citation.endPage | 1269 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | INDUCED HEARING-LOSS | - |
dc.subject.keywordPlus | COCHLEAR | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordAuthor | Gentamicin | - |
dc.subject.keywordAuthor | Hair cells NecroX | - |
dc.subject.keywordAuthor | Ototoxicity | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.