Associations Between TNFAIP3 Gene Polymorphisms and Systemic Lupus Erythematosus: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T16:14:55Z | - |
dc.date.available | 2021-09-06T16:14:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1945-0265 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107634 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether the tumor necrosis factor-alpha-inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. Methods: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and SLE susceptibility, using fixed and random effects models. Results: A total of eight comparative studies were included in this meta-analysis, which included four Asian, three European, and one African American population. Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p < 1.0 x 10(-9)). After stratification by ethnicity, the minor allele of rs2230926 was found to be significantly associated with SLE in Asians and Europeans (OR 1.821, 95% CI 1.495-2.219, p < 1.0 x 10(-9); OR 2.251, 95% CI 1.830-2.768, p < 1.0 x 10(-9)). In addition, a significant association was found between the minor allele of the rs5029939 polymorphism and the risk of developing SLE in all study subjects and Europeans (OR 1.804, 95% CI 1.255-2.592, p = 0.001; OR 2.145, 95% CI 1.731-2.658, p < 1.0 x 10(-9)). Furthermore, an association was found between the minor allele of rs3757173 and SLE in all study subjects (OR 1.540, 95% CI 1.017-2.331, p = 0.041). However, no association was found between SLE susceptibility and rs6922466 (OR 0.953, 95% CI 0.812-1.120, p = 0.561). Conclusions: This meta-analysis confirms that the TNFAIP3 polymorphisms are associated with SLE susceptibility in different ethnic groups, namely in Asians and Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT INC | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | JAPANESE POPULATION | - |
dc.subject | SUSCEPTIBILITY LOCI | - |
dc.subject | NEPHRITIS | - |
dc.subject | RESPONSES | - |
dc.subject | RISK | - |
dc.subject | A20 | - |
dc.title | Associations Between TNFAIP3 Gene Polymorphisms and Systemic Lupus Erythematosus: A Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1089/gtmb.2012.0096 | - |
dc.identifier.scopusid | 2-s2.0-84866250800 | - |
dc.identifier.wosid | 000308749500020 | - |
dc.identifier.bibliographicCitation | GENETIC TESTING AND MOLECULAR BIOMARKERS, v.16, no.9, pp.1105 - 1110 | - |
dc.relation.isPartOf | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.title | GENETIC TESTING AND MOLECULAR BIOMARKERS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1105 | - |
dc.citation.endPage | 1110 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | JAPANESE POPULATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | NEPHRITIS | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | A20 | - |
dc.subject.keywordAuthor | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordAuthor | JAPANESE POPULATION | - |
dc.subject.keywordAuthor | SUSCEPTIBILITY LOCI | - |
dc.subject.keywordAuthor | NEPHRITIS | - |
dc.subject.keywordAuthor | RESPONSES | - |
dc.subject.keywordAuthor | RISK | - |
dc.subject.keywordAuthor | A20 | - |
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